Formulasi dan Evaluasi Sediaan Body Lotion Ekstrak Etanol Kulit Jeruk Manis (Citrus x aurantium L.)

Authors

  • Embun Larasati Kuncoro Universitas Negeri Semarang
  • Naswa Salsabila Universitas Negeri Semarang
  • Margaret Rianti Martalina Universitas Negeri Semarang
  • Renata Amalia Azizah Universitas Negeri Semarang
  • Zefanya Yoga Permana Purba Universitas Negeri Semarang

DOI:

https://doi.org/10.55606/innovation.v4i2.9110

Keywords:

Antioxidant, Body Lotion, Citrus x aurantium L., DPPH, Physical Evaluation

Abstract

Sweet orange peel (Citrus x aurantium L.) is an agricultural by-product rich in bioactive compounds including flavonoids, phenolics, terpenoids, and vitamin C with antioxidant and moisturizing potential. This study aimed to formulate and evaluate a body lotion using 15% ethanol extract of sweet orange peel obtained by maceration with 96% ethanol. Evaluations included organoleptic, homogeneity, pH, adhesion, spreadability, viscosity, irritation, cycling test, cream type, and DPPH antioxidant activity assessments. The preparation was semisolid, yellow, with a characteristic herbal aroma, homogeneous, pH 8, adhesion time of 4.10 seconds, spreadability of 9.9–11.1 cm, and acceptable viscosity. The preparation caused no skin irritation, remained stable through six cycling test cycles, and formed an oil-in-water (O/W) emulsion. Antioxidant activity showed an IC₅₀ of 284.6 ppm (weak category) compared to vitamin C as positive control (IC₅₀ 4.2 ppm). It was concluded that ethanol extract of sweet orange peel can be formulated into a stable and safe body lotion, though further optimization is needed to enhance its antioxidant activity.

Downloads

Download data is not yet available.

References

Ahranjani, P. J., Esfandiari, Z., & Nodeh, H. R. (2025). A systematic review of traditional and eco-friendly methods for extracting bioactive compounds from Citrus aurantium L. plant. Journal of Food Composition and Analysis, 142, 107472. https://doi.org/10.1016/j.jfca.2025.107472

Agarwal, P., Shukla, R., & Tripathi, P. (2022). Citrus essential oils: Extraction, composition, and applications in food and cosmetics. Journal of Essential Oil Research, 34(2), 112–128.

Al-Barghouthy, E. Y., Hamed, S., Mehyar, G. F., & AlKhatib, H. S. (2025). Comparative evaluation of spreadability measurement methods for topical semisolid formulations: A scoping review. Gels, 11(12), 1006. https://doi.org/10.3390/gels11121006

Alfaridz, F., & Musfiroh, I. (2020). Interaksi antara zat aktif dan eksipien dalam sediaan farmasi. Majalah Farmasetika, 5(1), 23–31. https://doi.org/10.24198/mfarmasetika.v5i1.25755

Aljannah, F. W., Oktavia, S., & Noviyanto, F. (2022). Formulasi dan evaluasi sediaan hand body lotion ekstrak etanol daun semangka (Citrullus lanatus) sebagai antioksidan. Formosa Journal of Applied Sciences, 1(5), 799–818. https://doi.org/10.55927/fjas.v1i5.1483

Alqushay, H. D. G., Sri, B., & Tommy, J. (2024). Optimasi dan formulasi sediaan gel ekstrak etanol (Hydrocotyle verticillata Thub) dengan variasi konsentrasi HPMC dengan penambahan asam usnat. Jurnal Riset Ilmu Kesehatan Umum, 2(1). https://doi.org/10.57213/jrikuf.v2i1.155

Andriawan, A. I., & Taufik. (2025). Pembuatan dan uji mutu fisik sediaan body lotion pati bengkuang (Pachyrhizus erosus L.). Jurnal Kesehatan Yamasi Makassar, 9(1), 124–131. https://doi.org/10.59060/jurkes.v9i2.387

Anggun, T. W., & Setyo, N. (2023). Optimasi basis HPMC dan Na CMC dalam sediaan gel kulit buah semangka (Citrullus lanatus) serta aktivitas antibakterinya terhadap Staphylococcus aureus. Journal of Pharmacy, 2(1).

Arantika, J., & Hidayati, H. (2024). Pengaruh perbedaan konsentrasi ekstrak etanol kulit jeruk siam (Citrus nobilis var. microcarpa) terhadap uji stabilitas fisik dan kelembaban kulit pada sediaan lotion. Majalah Farmasetika, 9(2), 153–166. https://doi.org/10.24198/mfarmasetika.v9i2.50967

Auliasari, N., Hindun, S., Rantika, N., Yuningsih, R., & Hamidah, M. (2025). Formulasi dan evaluasi sediaan body butter ekstrak kulit jeruk manis (Citrus × aurantium L.) sebagai pelembab. Jurnal Kesehatan Bakti Tunas Husada, 25(2), 43–51. https://doi.org/10.36465/jkbth.v25i2.1684

Ayu, R. V., Metha, A. A., & Nur, E. (2022). Formulasi hand and body lotion ekstrak daun sambiloto dengan setil alkohol sebagai stiffening agent. Cendekia Journal of Pharmacy, 6(1). https://doi.org/10.31596/cjp.v6i1.147

Azmir, J., Zaidul, I. S. M., Rahman, M. M., Sharif, K. M., Mohamed, A., Sahena, F., & Omar, A. K. (2013). Techniques for extraction of bioactive compounds from plant materials: A review. Journal of Food Engineering, 117(4), 426–436. https://doi.org/10.1016/j.jfoodeng.2013.01.014

Badruddoza, A. Z. M., Yeoh, T., Shah, J. C., & Walsh, T. (2025). Assessing and predicting physical stability of emulsion-based topical semisolid products: A review. Journal of Pharmaceutical Sciences, 112(7), 1772–1793. https://doi.org/10.1016/j.xphs.2023.03.014

Departemen Kesehatan Republik Indonesia. (2020). Farmakope Indonesia (Edisi VI). Departemen Kesehatan Republik Indonesia.

Douguet, M., Picard, C., Savary, G., Merlaud, F., Loubat-Bouleuc, N., & Grisel, M. (2017). Spreading properties of cosmetic emollients: Use of synthetic skin surface to elucidate structural effect. Colloids and Surfaces B: Biointerfaces, 154, 307–314. https://doi.org/10.1016/j.colsurfb.2017.03.028

Durmus, N., Gulsunoglu-Konuşkan, Z., & Kilic-Akyilmaz, M. (2024). Recovery, bioactivity, and utilization of bioactive phenolic compounds in citrus peel. Food Science & Nutrition, 12(12), 9974–9997. https://doi.org/10.1002/fsn3.4570

Erlangga, D., Oktavianty, H., & Sunardi. (2024). Formulasi pembuatan hand & body lotion dari asam stearat dan defect roasted bean. Jurnal Innovative, 7(2).

Fatonah, N., Dwiningrum, R., Safutri, W., & Rosanti, A. S. (2025). Formulasi dan evaluasi sediaan lotion dari ekstrak daun sukun (Artocarpus altilis) sebagai antioksidan. Jurnal Inovatif dan Kreativitas, 5(2), 19659–19673. https://doi.org/10.55093/herbapharma.v5i2.416

Hafifah, F. N., Agustina, L. S., & Latifah, N. (2025). Review formulasi dan evaluasi stabilitas fisik sediaan krim berbahan alam: Tinjauan berbasis berbagai metode uji (cycling, freeze-thaw, sentrifugasi). Sains Medisina, 3(5), 320–328. https://doi.org/10.63004/snsmed.v3i5.738

Herlina, H., Paramita, D., Pitriani, P., & Sirumapea, L. (2024). Pengembangan lotion tubuh dari ekstrak etanol temulawak (Curcuma xanthorrhiza Roxb.) sebagai antioksidan. Jurnal Farmasi, 6(2), 163–172. https://doi.org/10.35451/jfm.v6i2.2093

Hidayati, S. M., Purwati, E., Puspadina, V., & Safitri, C. I. N. H. (2021). Formulasi dan uji mutu fisik body lotion ekstrak kulit buah apel Fuji (Malus domestica). In Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) (pp. 312–318).

Hudairiah, N. N., Rosalinda, S., & Widyasanti, A. (2021). Formulasi handbody lotion (setil alkohol dan karagenan) dengan penambahan ekstrak delima merah. Teknotan: Jurnal Industri Teknologi Pertanian, 15(2), 1–8. https://doi.org/10.24198/jt.vol15n1.7

Husni, P., Ruspriyani, Y., & Hasanah, U. (2022). Formulasi dan uji stabilitas fisik sediaan lotion ekstrak kering kulit kayu manis (Cinnamomum burmannii). Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi, 10(1), 1–7. https://doi.org/10.53675/jsfar.v10i1.396

Irmayanti, M., Rosalinda, S., & Widyasanti, A. (2021). Formulasi hand body lotion (setil alkohol dan karagenan) dengan penambahan ekstrak kelopak rosela. Teknotan: Jurnal Industri Teknologi Pertanian, 15(1), 47. https://doi.org/10.24198/jt.vol15n1.8

Jin, X., Imran, M., & Mohammed, Y. (2022). Topical semisolid products: Understanding the impact of metamorphosis on skin penetration and physicochemical properties. Pharmaceutics, 14(11), 2487. https://doi.org/10.3390/pharmaceutics14112487

Lestari, S. B., Waris, M. A. A., & Setyani, I. K. (2024). Formulasi dan uji mutu fisik sediaan body lotion ekstrak daun alpukat (Persea americana Mill.) dengan variasi konsentrasi trietanolamin dan asam stearat sebagai emulgator. Nutriture Journal, 3(3), 96–102. https://doi.org/10.56359/pharmgen.v3i3.414

Morales, J., Medina, A., & Bermejo, A. (2025). Sustainable extraction of flavonoids from citrus waste: A fast and simple approach with UHPLC-PDA ESI-MS characterization. Sci, 7(4), 156. https://doi.org/10.3390/sci7040156

Nurfita, E., Mayefis, D., & Umar, S. (2021). Uji stabilitas formulasi hand and body cream ekstrak etanol kulit buah naga merah (Hylocereus lemairei). Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 8(2), 125–131. https://doi.org/10.20473/jfiki.v8i22021.125-131

Patmayuni, D., Cempaka, R., & Rendowaty, A. (2023). Ekstrak etanol daun alpukat (Persea americana Mill.): Formulasi krim dan potensinya sebagai antijerawat. Jurnal Ilmiah Bakti Farmasi, 8(1), 25–32. https://doi.org/10.61685/jibf.v8i1.98

Romadhon, F. A., Wilapangga, A., & Fatwami, E. F. (2023). Formulasi dan uji fisik hand and body lotion sari buah tomat (Solanum lycopersicum L.) yang berkhasiat sebagai antioksidan. Indonesian Journal of Pharmaceutical Education, 3(3), 497–504. https://doi.org/10.37311/ijpe.v3i3.22744

Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (Eds.). (2009). Handbook of pharmaceutical excipients (6th ed.). Pharmaceutical Press.

Royyatun, Alrosyidi, A. F., & Syaifiyatul, H. (2024). Formulasi dan uji fisik sediaan body lotion ekstrak kombinasi daun alpukat (Persea americana Mill.) dan kulit jeruk nipis (Citrus aurantifolia [Christm.] Swingle) sebagai pelembab. FASKES: Jurnal Farmasi, Kesehatan, dan Sains, 2(1), 168–178. https://doi.org/10.32665/faskes.v2i1.3268

Rusli, N., Reymon, R., Fauziah, Y., & Sarnaeni, S. (2023). Formulasi sediaan lotion antioksidan fraksi etil asetat rimpang Meistera chinensis. Warta Farmasi, 12(2), 25–36.

Shi, L., Zhao, W., Yang, Z., Subbiah, V., & Suleria, H. A. R. (2022). Extraction and characterization of phenolic compounds and their potential antioxidant activities. Environmental Science and Pollution Research, 29(54), 81112–81129. https://doi.org/10.1007/s11356-022-23337-6

Standar Nasional Indonesia. (1996). Standar nasional Indonesia: Sediaan tabir surya. Badan Standardisasi Nasional.

Suena, N. M. D. S., Krismawati, N. K. P., & Suradnyana, I. G. M. (2022). Cycling test body butter maserat biji Coffea canephora dengan variasi asam stearat. Jurnal Ilmiah Farmasi, 11(3), 1–8. https://doi.org/10.30591/pjif.v12i1.2704

Syam, A. A. Y., & Marini, M. (2020). Optimasi formulasi sediaan handbody lotion dari ekstrak kulit jeruk bali (Citrus maxima [Burm.] Merr.) sebagai antioksidan. Jurnal Farmasi Muhammadiyah Kuningan, 5(2), 32–38. https://doi.org/10.55093/jurnalfarmaku.v5i2.135

Syaputri, F. N., Mulya, R. A., Tugon, T. D. A., & Wulandari, F. W. (2023). Formulasi dan uji karakteristik handbody lotion yang mengandung ekstrak etanol daun sirih merah (Piper crocatum). FARMASIS: Jurnal Sains Farmasi, 4(1), 13–22. https://doi.org/10.36456/farmasis.v4i1.6915

Wahyuni, F., Ningsih, W., & Rasyadi, Y. (2024). Pengaruh variasi setil alkohol dan cera alba terhadap sifat fisik lotion virgin coconut oil. JOPS (Journal of Pharmacy and Science), 7(2), 111–117. https://doi.org/10.36341/jops.v7i2.4685

Widiyanti, A. P., & Putri, S. A. (2025). Pengaruh variasi konsentrasi asam stearat dan trietanolamin terhadap evaluasi fisik sediaan lotion ekstrak daun stroberi (Fragaria × ananassa var. Duchesne). Jurnal Farmasindo Politeknik Indonusa Surakarta, 9(1), 252–254.

Yuniarsih, N., Warsito, A. M. A. P., Dinanti, D., Susanti, E. I., Mentari, M., Latif, M. Z., & Rades, R. A. (2023). Body lotion dari berbagai ekstrak tanaman. Journal of Pharmaceutical and Sciences, 6(2), 810–815. https://doi.org/10.36490/journal-jps.com.v6i2.142

Downloads

Published

2026-04-30

How to Cite

Embun Larasati Kuncoro, Naswa Salsabila, Margaret Rianti Martalina, Renata Amalia Azizah, & Zefanya Yoga Permana Purba. (2026). Formulasi dan Evaluasi Sediaan Body Lotion Ekstrak Etanol Kulit Jeruk Manis (Citrus x aurantium L.). Journal of Educational Innovation and Public Health, 4(2), 178–200. https://doi.org/10.55606/innovation.v4i2.9110