Moisturizers for Skin Barrier Repair: A Scoping Review of Transepidermal Water Loss and Stratum Corneum Hydration (2019-2026)

Kanaya Shabrina Maharani; Ghaisani Zata Dini; Novia Putri Ixanty; Zarifa Ramadani Nurulhuda; Azmi Hendina Putra

doi:10.55606/jig.v4i3.9318

Authors

Kanaya Shabrina Maharani Universitas Negeri Semarang
Ghaisani Zata Dini Universitas Negeri Semarang
Novia Putri Ixanty Universitas Negeri Semarang
Zarifa Ramadani Nurulhuda Universitas Negeri Semarang
Azmi Hendina Putra Universitas Negeri Semarang

DOI:

https://doi.org/10.55606/jig.v4i3.9318

Keywords:

Moisturizer, Scoping Review, Skin Barrier, Stratum Corneum Hydration, Transepidermal Water Loss

Abstract

The skin barrier is the outermost protective layer of the skin that plays an important role in maintaining skin hydration and preventing excessive water loss. Damage to the skin barrier can increase transepidermal water loss (TEWL), causing the skin to become dry, sensitive, and prone to irritation. Moisturizers are used to improve skin barrier function by increasing skin hydration and reducing TEWL. This study aimed to conduct a scoping review of moisturizer formulations for skin barrier repair based on transepidermal water loss (TEWL) and stratum corneum hydration parameters. The research method used was a scoping review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. Literature searches were conducted through Google Scholar, PubMed, ScienceDirect, and Semantic Scholar databases using research articles published between 2019–2026 related to the study topic. A total of 20 articles met the inclusion criteria, consisting of experimental formulation studies and clinical studies. The review results showed that moisturizers are available in various topical dosage forms such as gels, creams, lotions, serums, emulgels, and cleansers with herbal and modern active ingredients such as ceramide, niacinamide, sodium hyaluronate, and Centella asiatica extracellular vesicles (Cica EVs). Gel preparations were the most commonly used formulations because they have a light texture, are comfortable to use, and are easy to apply to the skin. In experimental studies, emulgel containing limpasu fruit extract showed the most optimal physical characteristics based on viscosity and spreadability parameters. Meanwhile, in clinical studies, ceramide-based moisturizers showed the best effectiveness in increasing skin hydration and significantly reducing TEWL. The effectiveness of moisturizers was also influenced by the combination of humectants, emollients, occlusives, and gelling agents in the formulation. Overall, moisturizers have good potential in increasing skin hydration and improving skin barrier function through reducing TEWL and increasing stratum corneum hydration.

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References

Aich, B., Kumbhar, P., Muchala, S., Sanghavi, A., Katare, S., & Kotak, B. (2024). Clinical evaluation of a topical ceramide lotion on skin hydration and skin barrier in healthy volunteers with dry skin. CosmoDerma, 4(148).

Ainurofiq, A., Rahmawati, D., Prasetyo, B., Hidayati, N., & Kusuma, A. (2023). Skin barrier and stratum corneum function in maintaining skin hydration. Journal of Pakistan Association of Dermatologists, 33(2), 450–457.

Alexander, H., Brown, S., Danby, S., & Flohr, C. (2018). Research techniques made simple: Transepidermal water loss measurement as a research tool. Journal of Investigative Dermatology, 138(11), 2295–2300.

Anjani, F. S., Rahmawati, D., & Yuwanda, A. (2024). Optimasi dan formulasi sediaan krim wajah ekstrak daun pegagan (Centella asiatica L.) sebagai antioksidan. Jurnal Farmasi Higea, 16(2), 170–176.

Arif, M., Faizatun., Purba, A. (2021). Formulasi Sediaan Gel Etosom Ekstrak Lamun (Enhalus acoroides) Sebagai Pencerah dan Pelembab Pada Kulit. Jurnal Kartika Kimia, 4(1), 1-13.

Arifin, A., Pakki, E., & Fitrah. (2023). Formulasi dan Uji Stabilitas Fisik Sediaan Losio Bubur Rumpur Laut (Eucheuma alvarezii) Asal Kabupaten Luwu Sulawesi Selatan. Pharmamedica Journal, 8(2), 174-184.

Baker, P., Christina, H., Rakan, R., Samara, B. M., Emmanuela, J., & Jack, L. A. (2023). Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties. Cells 2023, 12, 2745. https://doi.org/10.3390/cells12232745

Braun, C., Haftek, M., & Aubin, F. (2021). Five Functional Aspects of the Epiderm Barrier. International Journal of Molecular Sciences, 22, 2-14.

Butarbutar, M. E. T., & Chaerunisaa, A. Y. (2021). Peran pelembab dalam mengatasi kondisi kulit kering. Majalah Farmasetika, 6(1), 56–69.

Chang, T.-M., Wu, C.-C., Huang, H.-C., Lu, J.-Y., Chuang, C.-H., Kao, P.-L., Tang, W.-H., Liu, L. T.-C., Qiu, W.-Y., Percec, I., Chen, C., & Kuo, T.-Y. (2025). A 28-day pilot study of the effects on facial skin hydration, elasticity, and texture of a Centella asiatica extracellular vesicle-based skin care formulation. Cosmetics, 12(5), 186.

Dasopang, E. S., Harahap, U., Siregar, D. I., Nasution, M. P., & Hasibuan, P. A. Z. (2024). Formulasi dan evaluasi sediaan moisturizer terhadap kelembapan kulit. Biolink: Jurnal Biologi Lingkungan, Industri, Kesehatan, 11(1), 15–24.

Eryani, M., Siddiq, H., & Rashati, D. (2023). Pengaruh Variasi Konsentrasi HMPC Terhadap Sifat Fisik Gel Kulit Ekstrak Pisang Agung Semeru (Musa paradisiaca L.). Jurnal Riset Kefarmasian Indonesia, 5(1), 12-23.

Farida, S. N., Agustina, A., & Mahdi, N. (2022). Formulasi Dan Evaluasi Sifat Fisik Sediaan Krim Pelembab Wajah (Moisturizer) Dari Ekstrak Etanol Daun Ginseng Jawa (Talinum paniculatum gaertn). BORNEO JOURNAL OF PHARMASCIENTECH, 6(2), 104 -107.

Green, M., Kashetsky, N., Feschuk, A., & Maibach, H. I. (2022). Transepidermal water loss (TEWL): Environment and pollution-A systematic review. Skin Health and Disease, 2(2), 104.

Harris, S., Khunti, K., & Blonde, L. (2018). Interpretation and Impact of Real-World Clinical Data for the Practicing Clinician. Advanced Therapies Journal, 35, 1763-1774.

Hastuti, R., Endah, S. R. N., & Nofriyald, A. (2020). Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Alpukat (Persea americana Mill). Pharmacoscript, 3(2), 150–161.

Janitra, F., Kustanti, C., Aini, N. (2024). Metode Penelitian Eksperimental. Jurnal Kesehatan, 11(2), 67-79.

Kharisma, P. N., Listyani, T. A., & Hidayat, R. (2025). Formulasi Dan Uji Stabilitas Sediaan Gel Moisturizer Ekstrak Umbi Bit (Beta Vulgaris L.). JURNAL KESEHATAN TAMBUSAI, 6(3), 13299 - 13307.

Kim, B. E., & Donald, Y. M. L. (2018). Signifikansi Disfungsi Penghalang Kulit pada Dermatitis Atopik. Departemen Pediatri, National Jewish Health, Denver, CO, AS https://doi.org/10.4168/aair.2018.10.3.207 pISSN 2092-7355 • eISSN 2092-7363

Kristianingsih, I., Susianti, T. D., Lailiyah, M., & Sari, F. (2025). Uji aktivitas gel moisturizer anti aging tomat (Solanum lycopersicum L.) dan bunga mawar merah (Rosa × damascena Herrm.) sebagai antioksidan. Jurnal Wiyata, 12(1).

Lely, O., Rika, y., Firman, G., & Indra. (2025). Optimasi Formulasi Emulgel Topikal Berbasis Minyak Zaitun: Peran Gelling Agent Terhadap Viskositas, PH, Daya Sebar, Dan Keamanan. Jurnal Kesehatan Bakti Tunas Husada, 25(2), 1-10

Lestari, R., Gifanda, L., & Kurniasari, E. (2021). PERILAKU MAHASISWA TERKAIT CARA MENGATASI JERAWAT. Jurnal Farmasi Komunitas, 8(1), 15-19.

Mutiara Syahria, Nurlina, N., & Iskandar Zulkarnain. (2026). Formulasi Dan Evaluasi Efektivitas Kelembaban Sediaan Gel Lidah Buaya (Aloe vera Linn). Nusantara Hasana Journal, 5(11), 30–43.

Ningsih, K., Darsono, F., & Wijaya, S. (2019). Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Pepaya (Carica papaya L.). Journal of Pharmacy and Practice, 6(1), 49-56.

Nugroho, R., Kim, J. E., Lee, H. S., Park, S. Y., & Choi, M. J. (2023). Moisturizers and their role in skin barrier function. Clinical, Cosmetic and Investigational Dermatology, 16, 1457–1468.

Okzelia, S., & Mardiyyah, W. (2023). Formulasi dan Evaluasi Gel Pelembab Ekstrak Mesokarp Semangka (Citrullus lanatus (Thunb.)) sebagai Antioksidan. Journal of Pharmaceutical and Health Research, 4(1), 30-39.

Park, J. H., Choi, Y., Jung, Y. J., Lee, T., Kim, H., Cho, Y., & Lee, J. H. (2024). Skin hydration measurement: Comparison between devices and clinical evaluations. Annals of Dermatology, 36(5), 275-281.

Prihadi, I. A., Ellistasari, E. Y. Kusumawardani, A. (2022). The Difference In Transepidermal Water Loss (TEWL) Values Between Sun-exposed and Non-sun-exposed Skin Among Male Medical Students. Journal of General - Procedural Dermatology & Venereology Indonesia, 6(2), 18-21.

Prima, H. R., Fajrina, H., & Mia, F. (2019). Stabilitas Fisik Sediaan Emulgel Ekstrak Etanol Daging Buah Limpasu (Baccaurea lanceolata (Miq.) Müll. Arg.). Jurnal Pharmascience, 06(02), 8 - 18.

Putri, W., & Anindhita, M. (2022). Optimiasi Formula Gel Ekstrak Etanol Buah Kapulaga dengan Kombinasi Gelling Agent HMPC dan Natrium Alginat Menggunakan Simplex Lattic Design. Jurnal Ilmiah Farmasi, 2(1), 107-120.

Rahmawati, D., Hasanah, U., & Pratiwi, A. (2022). Formulasi dan uji stabilitas fisik gel ekstrak etil asetat daun sirih hijau (Piper betle L) menggunakan variasi basis gel. Fito Medicine: Journal Pharmacy and Sciences, 14(1), 33–41.

Ramadani, F., Ardiyantoro, B., & Fitriawati, A. (2026). Evaluasi Uji Mutu Fisik Dan Uji Stabilitas Sediaan Gel Moisturizer Ekstrak Etanol Kulit Buah Jeruk Kalamansi (Citrus Microcarpa Bunge). JURNAL KESEHATAN TAMBUSAI, 7(1), 4292 - 4301.

Rani, F. M., Wicahyo, S, M., & Wardani, T. S. (2025). Formulasi Sediaan Gel Moisturizer Ekstrak Daun Kirinyuh (Chromolaena Odorata) Dengan Uji Antioksidan, Uji Mutu Fisik Dan Uji Stabilitas Fisik. JURNAL KESEHATAN TAMBUSAI, 6(3), 13812 - 13823.

Rehman, U., & Sabir, S. (2026). Comparative study of organic vs synthetic emollients in skin moisturizers: Evaluating efficacy, barrier function, and patient satisfaction in a randomized controlled trial. Journal of Medical & Health Sciences Review, 3(1), 407-415.

Sembiring, P., & Harahap, N. D. (2026). Formulasi dan uji stabilitas fisik serta penentuan nilai SPF (Sun Protecting Factor) gel moisturizer ekstrak etanol daun kelakai (Stenochlaena palustris (Burm. f.) Bedd.). Jurnal Farmasi dan Herbal, 8(2), 22–31.

Shafira, R., Sari, D. O., & Agung S. E. (2021). Formulasi dan Evaluasi Gel Dari Ekstrak Kulit Putih Semangka (Citrullus Lanatus [Thunb.] Matsum. & Nakai) Sebagai Pelembab kulit. Jurnal Sabdariffarma, 9(2), 33-46.

Spada, F., Harrison, I. P., Barnes, T. M., Greive, K. A., Daniels, D., Townley, J. P., Mostafa, N., Fong, A. T., Tong, P. L., & Shumack, S. (2021). A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial. Dermatologic Therapy, 34(4), e14970.

Tempark, T., Shem, A., & Lueangarun, S. (2024). Efficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial. Journal of Cosmetic Dermatology, 23(5), 1758-1765.

Tutik, F., Qomariyah, L., & Putri, M. (2025). Manfaat Ceramide Untuk Perawatan Kulit. Majalah Farmasetika, 10(1), 1-16.

Yuliani, R., Wahyuni, S., & Fitriani, N. (2021). Uji stabilitas fisik formula sediaan gel ekstrak daun kelor (Moringa oleifera Lamk.). Jurnal Ilmiah Kesehatan, 10(2), 85–92.