Potensi Senyawa Bioaktif Mangrove sebagai Bahan Aktif Fungsional dalam Formulasi Lip Balm
A Systematic Literature Review
DOI:
https://doi.org/10.55606/jurrimipa.v5i1.9532Keywords:
Antioxidant Activity, Lip Balm, Mangrove Extract, Natural Cosmetics, PhytochemicalsAbstract
The increasing demand for natural and environmentally sustainable cosmetic products has stimulated interest in utilizing mangrove-derived bioactive compounds as alternative ingredients in lip balm formulations. Mangrove species are recognized as rich sources of secondary metabolites, including flavonoids, polyphenols, tannins, terpenoids, and natural lipids, which exhibit antioxidant and protective properties beneficial for lip care applications. This study aimed to systematically evaluate the potential of mangrove species as active ingredients in lip balm formulations by examining their phytochemical characteristics, antioxidant activities, and formulation performance. A Systematic Literature Review approach was employed following the PRISMA framework, involving the collection, screening, and synthesis of relevant studies published between 2020 and 2025. Eighteen eligible primary research articles were included in the final analysis. The results demonstrated that Sonneratia alba, Bruguiera gymnorrhiza, Ceriops tagal, Rhizophora mucronata, and Avicennia marina possess diverse bioactive compounds and promising antioxidant activities, with several species exhibiting very strong antioxidant capacity based on IC₅₀ values. Furthermore, lip balm formulations containing mangrove extracts generally fulfilled cosmetic quality requirements, including appropriate pH, good homogeneity, acceptable melting points, physical stability, and non-irritating properties. These findings highlight the potential of mangrove extracts as multifunctional natural ingredients for developing safe, effective, and sustainable lip balm products, while supporting the value-added utilization of coastal biological resources and promoting future innovation in natural cosmetic formulations.
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References
Botutihe, N. (2024). Formulation and physical stability test of lip balm preparation of mangosteen peel extract. Journal of Health, Technology and Science, 4(4). https://doi.org/10.47918/jhts.v4i4.1617
Cerri, F., Beatrice D., Spena F., Salvioni L., Forcella M., Fusi P., Pagliari S., Stahl H., Galli P., Colombo M., Giustra M., Campone L. (2025). Phytochemical profiling, antioxidant activity, and in vitro cytotoxic potential of mangrove Avicennia marina. Pharmaceuticals, 18(9), 1308. https://doi.org/10.3390/ph18091308
Das, P., Ashrafi, S., Anjum, J., Hossain, M. E., Reza, M. S., & Ahsan, M. (2024). Isolation of terpenoids and derivatives from a Bangladeshi mangrove plant, Rhizophora mucronata Lam., and its bioactivity evaluation: In vitro and in silico study. Journal of Chemistry, 2024, Article 8884812. https://doi.org/10.1155/2024/8884812
Dotulong, L. A., Montolalu, L. A. D. Y., & Reo, A. R. (2024). Aktivitas antioksidan daun muda mangrove Sonneratia alba segar asal pesisir Desa Wori Sulawesi Utara. Media Teknologi Hasil Perikanan, 12(1), 32–40. https://doi.org/10.35800/mthp.12.1.2024.51673
Faiqoh, M., Utami, T. F. Y., & Pertiwi, Y. (2020). Uji antioksidan sediaan stick balm ekstrak daun Rhizophora mucronata dengan metode DPPH. Journal of Pharmaceutical Health and Sciences (JOPHUS), 2(1). https://doi.org/10.46772/JOPHUS.V2I01.277
Fatminati, I., Asikin, A. N., Zuraida, I., Irawan, I. R., & Mismawati, A. (2022). Penambahan ekstrak buah pedada (Sonneratia alba) sebagai antioksidan alami pada pembuatan skin lotion. Jurnal Kelautan dan Perikanan Terapan, 5(2), 143–151. https://doi.org/10.15578/jkpt.v5i2.10679
Hoang, H. T., Moon, J. Y., & Lee, Y. C. (2021). Natural antioxidants from plant extracts in skincare cosmetics: Recent applications, challenges and perspectives. Cosmetics, 8(4), 106. https://doi.org/10.3390/cosmetics8040106
Khadeeja, S., Ragunathan, R., Johney, J., & Muthusamy, K. (2022). Phytochemical analysis, antimicrobial and antioxidant activity of mangrove plants Bruguiera gymnorrhiza (L.) Lam. and Excoecaria agallocha L. Indian Journal of Science and Technology, 15(47), 2594–2604. https://doi.org/10.17485/IJST/v15i47.1633
Mohamed, A. S., Elmi, A., & Abdoul-Latif, F. M. (2025). Phytochemical analysis and bioactivities of Rhizophora mucronata Lam. from Djibouti: In vitro and in silico approaches. Journal of Pharmacognosy and Phytochemistry, 14(5), 348–368. https://doi.org/10.22271/phyto.2025.v14.i5e.15592
Murugesan, S., Kandhavelu, J., Thiyagarajan, R., Natesan, S., Rajendran, P., & Murugesan, R. (2023). Marine halophyte-derived polyphenols inhibit glioma cell growth through mitogen-activated protein kinase signaling pathway. Biomedicine & Pharmacotherapy, 166, 114288. https://doi.org/10.1016/j.biopha.2023.114288
Nazliniwaty, N. (2020). Pemanfaatan ekstrak kulit buah delima (Punica granatum L.) dalam formulasi sediaan lip balm. Jurnal Jamu Indonesia, 4(3). https://doi.org/10.29244/JJI.V4I3.100
Omidian, H., Akhzarmehr, A., & Bertol, C. D. (2025). Natural-based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications. International Journal of Cosmetic Science. Int J Cosmet Sci. 2026;48:394–427. https://doi.org/10.1111/ics.70039Digital Object Identifier (DOI)
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., & Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71
Pamela, P. (2023). Formulasi dan penentuan nilai SPF (Sun Protection Factor) gel tabir surya ekstrak metanol daun perepat (Sonneratia alba) secara in vitro (Skripsi Sarjana). Universitas Jambi, Jambi, Indonesia.
Permatasari, L., Muliasari, H., & Ilmi, H. (2025). Principal component analysis (PCA) of total phenolic content, antioxidant and antimalarial activities of Rhizophora mucronata, Avicennia marina, and Sonneratia alba leaves from Lombok Island. Research Journal of Pharmacy and Technology. https://doi.org/10.52711/0974-360X.2025.00545
Priyanto, R. A., & Rimba, F. (2023). Antioxidant activity and bioactive compound in mangrove fruit (Rhizophora mucronata Lamk.). Jurnal Ilmiah Platax, 11(2). https://doi.org/10.35800/jip.v11i2.48758
Putri, D. B., Pringgenies, D., & Trianto, A. (2025). Antibacterial, antifungal, antioxidant, and photoprotective analysis of mangrove extracts as additive ingredients in a cosmetic cream. Hayati Journal of Biosciences, 32(3), 571–580. https://doi.org/10.4308/hjb.32.3.571-580
Rahman, I. R., et al. (2025). Lip balm ekstrak kulit buah tampoi: Formulasi, SPF dan uji iritasi. Jurnal Ilmiah Farmako Bahari, 17(1). https://doi.org/10.52434/jifb.v17i1.43301
Ridhani, A., Budi, S., & Hidayah, N. (2022). Formulasi dan evaluasi stabilitas sediaan lip balm ekstrak buah mahkota dewa (Phaleria macrocarpa). SNSMED Journal, 1(1), 9–16. https://doi.org/10.63004/snsmed.v1i1.5
Riyadi, P. H., Tanod, W. A., Dewanto, D. K., Herawati, V. E., Susanto, E. H., & Aisiah, S. (2021). Chemical profiles and antioxidant properties of Bruguiera gymnorrhiza fruit extracts from Central Sulawesi, Indonesia. Food Research, 5(Supplement 3), 37–47. https://doi.org/10.26656/fr.2017.5(S3).007
Rozirwan, Hananda, H., Nugroho, R. Y., Apri, R., Khotimah, N. N., Fauziyah, Putri, W. A. E., & Aryawati, R. (2023). Antioxidant activity, total phenolic, phytochemical content, and HPLC profile of selected mangrove species from Tanjung Api-Api Port Area, South Sumatra, Indonesia. Tropical Journal of Natural Product Research, 7(7). https://doi.org/10.26538/tjnpr/v7i7.29
Sachithanandam, V., et al. (2020). Biological evaluation of gallic acid and quercetin derived from Ceriops tagal: Insights from extensive in vitro and in silico studies. Journal of Biomolecular Structure and Dynamics. https://doi.org/10.1080/07391102.2020.1828173
Safitri, N., Yuniarti R., Indrayani G., Sari M. (2025). Evaluasi mutu fisik, uji kelembapan dan potensi aktivitas tabir surya pelembab bibir ekstrak etanol daun pucuk merah (Syzygium myrtifolium Walp.). Journal of Pharmaceutical and Sciences, 8(4), 2262–2275. https://doi.org/10.36490/journal-jps.com.v8i4.1052
Tanod, W. A., Dewanto, D. K., & Cahyono, E. (2025). GC-MS and ADMET profiling of Bruguiera gymnorrhiza mangrove leaf extract origin Sulawesi with antioxidant properties. Jurnal Kimia dan Pendidikan Kimia (JKPK), 10(1). https://doi.org/10.20961/jkpk.v10i1.100362
Thakur, B. K., Puneet, Singh, G., & Kaur, H. (2025). Herbal skincare: Formulation, testing and analysis of moisturizer and lip balm. International Journal of Scientific Research in Science and Technology, 12(3), 557–569. https://doi.org/10.32628/IJSRST2512366
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