Review Metode Ekstraksi : Maserasi, Perkolasi, Infusa, Soxhlet, Refluks, Ultrasonic Assisted Extraction (UAE), dan Microwave Assisted Extraction (MAE)

Authors

  • Amaliya Bunga Dwiyanti Universitas Muhammadiyah Banjarmasin
  • Devira Niken Putri Ferdinand Universitas Muhammadiyah Banjarmasin
  • Mifta Dewi Universitas Muhammadiyah Banjarmasin
  • Musa’adah Musa’adah Universitas Muhammadiyah Banjarmasin
  • Noor Mila Wati Universitas Muhammadiyah Banjarmasin
  • Rima Hindriani Universitas Muhammadiyah Banjarmasin

DOI:

https://doi.org/10.55606/jurrike.v4i3.6465

Keywords:

Extraction Method, Maceration, MAE, Natural Products, UAE

Abstract

Extraction is a crucial process for obtaining active compounds from natural materials, such as medicinal plants, spices, and other biomass. The success of the extraction process is greatly influenced by the method used, as each method has its own mechanism, efficiency, and yield. This study compared seven commonly used extraction methods: maceration, percolation, infusion, soxhletation, reflux, Ultrasound-Assisted Extraction (UAE), and Microwave-Assisted Extraction (MAE). Based on data collected from various scientific journals, it was found that modern methods such as UAE and MAE are capable of producing higher yields than conventional methods. Furthermore, both methods are more efficient in terms of extraction time and solvent usage, making them more environmentally friendly and suitable for industrial-scale applications. However, conventional methods such as maceration and percolation still play an important role, especially in initial research or in laboratories with limited equipment. For example, maceration is easy to perform, does not require high energy, and is suitable for heat-sensitive materials. Other factors that influence extraction results include the type of solvent, temperature, time, and the characteristics of the natural material itself. Therefore, the choice of extraction method must be tailored to the research objectives, the type of compound to be extracted, and the availability of resources and equipment. Combining several methods can also be considered to improve the efficiency and quality of the extraction results. It should be emphasized that extraction yield is influenced not only by the method, but also by the type of material, solvent, temperature, time, and particle size. Therefore, the choice of extraction method must be tailored to the nature of the material, the type of target compound, as well as the objectives and availability of resources. In some cases, a combination of extraction methods can also be used to increase efficiency and obtain optimal results.

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References

Amin, A., Waris, R., & Sari, R. (2024). Nilai rendemen dan analisis fitokimia ekstrak daun pecut kuda (Stachytarpheta jamaicensis) berdasarkan lama ekstraksi dengan metode ultrasonic assisted extraction. Gema Kesehatan, 16(2), 112–121. https://doi.org/10.47539/gk.v16i2.469

Astriani, N., Chusniasih, D., & M., S. (2021). Uji aktivitas antibakteri ekstrak daun jeruk purut (Citrus hystrix) terhadap bakteri Escherichia coli dan Staphylococcus aureus. Jurnal Ilmu Kedokteran dan Kesehatan, 8(September), 291–301.

Elya, B., Forestrania, R. C., Hashim, N. M., & Triadisti, N. (2024). Dipeptidyl peptidase-4 inhibition of Peronema canescens Jack leaves and stems: Bioassay-guided fractionation, compound profiling by LC-MS/MS, and interaction mechanism. Journal of Applied Pharmaceutical Science, 14(7), 90–101. https://doi.org/10.7324/JAPS.2024.161007

Fadiyah, I., Lestari, I., & Mahardika, R. G. (2020). Kapasitas antioksidan ekstrak buah rukam (Flacourtia rukam) menggunakan metode microwave assisted extraction (MAE). Indonesian Journal of Chemical Research, 7(2), 107–113. https://doi.org/10.30598/ijcr.2020.7-ina

Kara, H. O. A. M. A. (2014). Pengaruh metode ekstraksi terhadap rendemen dan kualitas ekstrak herbal. Jurnal Keteknikan Pertanian (JTEP), 7(2), 107–115.

Handayani, F., Apriliana, A., & Ariyanti, L. (2019). Comparison of the maseration and refluks methods in herbal extraction. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 6(1), 33–42.

Handayani, I. A., Eliyanoor, B., & Ulva, D. D. (2016). Perbandingan kadar flavonoid ekstrak buah mahkota dewa (Phaleria macrocarpa [Scheff] Boerl) secara remaserasi dan perkolasi. Jurnal Ilmiah Ibnu Sina, 1(1), 79–87.

Handoyo, D. L. Y. (2020). The influence of maseration time (immeration) on the viscosity of birthleaf extract (Piper betle). Jurnal Farmasi Tinctura, 2(1), 34–41. https://doi.org/10.35316/tinctura.v2i1.1546

Ibrahim, Y. M., Dotulong, V., Wonggo, D., Lohoo, H. J., Montolalu, R. I., Makapedua, D. M., & Sanger, G. (2019). Aktivitas antibakteri infusa daun muda mangrove Sonneratia alba kering. Media Teknologi Hasil Perikanan, 7(2), 52. https://doi.org/10.35800/mthp.7.2.2019.23613

Koesnadi, A. E., Putra, I. N. K. P., & Wiadnyani, A. A. I. S. (2021). Pengaruh waktu ektraksi terhadap aktivitas antioksidan ekstrak daun rambusa (Passiflora foetida L.) menggunakan metode microwave assisted extraction (MAE). Jurnal Ilmu dan Teknologi Pangan (ITEPA), 10(3), 2021–2357.

Kristanti, Y., Widarta, I. W. R., & Permana, I. D. G. M. (2019). Pengaruh waktu ekstraksi dan konsentrasi etanol menggunakan metode microwave assisted extraction (MAE) terhadap aktivitas antioksidan ekstrak rambut jagung (Zea mays L.). Jurnal Ilmu dan Teknologi Pangan (ITEPA), 8(1), 94. https://doi.org/10.24843/itepa.2019.v08.i01.p11

Marlina Kristina, C. V., Yusasrini, N. L. A., & Yusa, N. M. (2022). Pengaruh waktu ekstraksi dengan menggunakan metode ultrasonic assisted extraction (UAE) terhadap aktivitas antioksidan ekstrak daun duwet (Syzygium cumini). Jurnal Ilmu dan Teknologi Pangan (ITEPA), 11(1), 13. https://doi.org/10.24843/itepa.2022.v11.i01.p02

Nursamsiar. (2022). Pengaruh metode ekstraksi terhadap aktivitas antioksidan ekstrak daun karamunting (Rhodomyrtus tomentosa (Aiton) Hassk) dengan metode DPPH. Jurnal Ilmiah Farmasi Farmasyifa, 5(2), 183–191. https://doi.org/10.29313/jiff.v5i2.9053

Oktavia, S. N., Wahyuningsih, E., Andasari, S. D., & Normaidah. (2020). Skrining fitokimia dari infusa dan ekstrak etanol 70% daun cincau hijau (Cyclea barbata Miers). CERATA Jurnal Ilmu Farmasi, 11(1), 1–6. https://doi.org/10.61902/cerata.v11i1.84

Pratama, A. R., Ariyanto, E., & Mardwita, M. (2021). Pengaruh volume solvent dan berat biji alpukat (Persea americana Mill) terhadap yield dan karakteristik hasil ekstraksi. Jurnal Teknik Kimia dan Lingkungan, 5(2), 115–127.

Putri, A., Nofita, N., & Ulfa, A. M. (2023). Perbandingan aktivitas antioksidan ekstrak daun bidara (Ziziphus spina-christi L.) dengan teknik ekstraksi perkolasi dan infusa. Jurnal Ilmu Kedokteran dan Kesehatan, 9(4), 1178–1189. https://doi.org/10.33024/jikk.v9i4.5635

Putri, V. M., Azzahra, F., Utami, A., Astuti, F., & Farmasi, A. (2024). Perbandingan rendemen dan kandungan kimia secara kualitatif ekstrak daun alpukat (Persea americana) berdasarkan perbedaan metode ekstraksi. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi, 24, 67–77.

Putri, D. V., Marcellia, S., & [Penulis lainnya]. (2022). Uji aktivitas antibakteri ekstrak kulit buah mahoni (Swietenia mahagoni (L.) Jacq) dengan perbandingan metode ekstraksi. Jurnal Ilmu Kedokteran dan Kesehatan, 9(1), 524–531. https://scholar.archive.org/work/si5zccmvjbfm3eacecdlc5q3zi/access/wayback/http://ejurnalmalahayati.ac.id/index.php/kesehatan/article/download/5441/pdf

Ramayani, S. L., Nugraheni, D. H., & Evan, A. R. (2021). Pengaruh metode ekstraksi terhadap fenolik dan kadar total flavonoid daun talas (Colocasia esculenta L.). Journal of Pharmacy, 10(1), 11–16.

Riset, J. (2022). Optimasi ekstraksi dari Capsicum frutescens L. dengan Microwave-Assisted Soxhlet Extraction (MASE) menggunakan Response Surface Methodology (RSM). Jurnal Riset Sains dan Teknologi, 5(2), 131–138.

Sari, I. P., Hidayati, A. R., & Muliasari, H. (2023). Perbandingan aktivitas antioksidan infusa simplisia segar dan simplisia kering daun buni (Antidesma bunius L. Spreng) dengan metode DPPH. Jurnal Sains dan Kesehatan, 5(5), 605–614. https://doi.org/10.25026/jsk.v5i5.1792

Sholikha, M., & Fathi, M. (2022). Uji aktivitas antidiabetes ekstrak daun senggani (Melastoma malabathricum L.) secara in vitro dengan metode penghambatan α-glukosidase. Jurnal Kesehatan Saelmakers, 3(2), 263–269.

Suarantika, F., Patricia, V. M., & Rahma, H. (2023). Optimasi proses ekstraksi daun sirih hijau (Piper betle L.) yang memiliki aktivitas antioksidan berdasarkan penggunaan secara empiris. Jurnal Ilmiah Medicamento, 9(1), 16–21. https://doi.org/10.36733/medicamento.v9i1.5253

Swara, I. M. A. B., Puspawati, G. A. K. D., & Widarta, I. W. R. (2023). Pengaruh waktu ekstraksi dengan metode microwave assisted extraction (MAE) terhadap aktivitas antioksidan ekstrak daun belimbing wuluh (Averrhoa bilimbi L.). Jurnal Ilmu dan Teknologi Pangan (ITEPA), 12(4), 939. https://doi.org/10.24843/itepa.2023.v12.i04.p14

Syamsul, E. S., Amanda, N. A., & Lestari, D. (2020). Perbandingan ekstrak lamur Aquilaria malaccensis dengan metode maserasi dan refluks. Jurnal Riset Kefarmasian Indonesia, 2(2), 97–104. https://doi.org/10.33759/jrki.v2i2.85

Tapalina, N., Tutik, T., & Saputri, G. A. R. (2022). Pengaruh metode ekstraksi panas terhadap aktivitas antioksidan ekstrak kulit bawang merah (Allium cepa L.). Jurnal Ilmu Kedokteran dan Kesehatan, 9(1), 492–500. https://doi.org/10.33024/jikk.v9i1.5830

Triadisti, N., Elya, B., Hanafi, M., & Hashim, N. M. (2025). Bioactive chromatographic fractions from Uncaria sclerophylla (W. Hunter) Roxb. leaves on dipeptidyl peptidase-4 inhibition and antioxidant capacity, phytochemicals, and compound profiling using UPLC-ESI-QToF-MS/MS. Journal of Pharmacy and Pharmacognosy Research, 13(1), 58–85. https://doi.org/10.56499/jppres24.2022_13.1.58

Triyanti, S. B., Lestari, F. P., Anisa, P., Fitriana, N., & Rostiana, H. R. (2025). Pengaruh metode ekstraksi maserasi, sonikasi, dan sokletasi terhadap nilai rendemen sampel kulit buah naga (Hylocereus polyrhizus). Jurnal Sains dan Edukasi Sains, 8(1), 71–78.

Tutik, T., Putri, G. A. R., & Lisnawati, L. (2022). Perbandingan metode maserasi, perkolasi, dan ultrasonik terhadap aktivitas antioksidan kulit bawang merah (Allium cepa L.). Jurnal Ilmu Kedokteran dan Kesehatan, 9(3), 913–923. https://doi.org/10.33024/jikk.v9i3.5634

Wadli, & Hasdar, M. (2021). Ekstraksi beras hitam sirampog berbantu gelombang mikro (Microwave Assisted Extraction [MAE]). Jurnal Pengolahan Pangan, 6(2), 49–53. https://doi.org/10.31970/pangan.v6i2.49

Widyapuri, D., Purbowati, I. S. M., & Wibowo, C. (2022). Pengaruh waktu ekstraksi menggunakan ultrasonic assisted extraction terhadap antosianin jantung pisang (Musa spp). Agrointek: Jurnal Teknologi Industri Pertanian, 16(2), 242–251. https://doi.org/10.21107/agrointek.v16i2.12559

Widyasanti, A., Halimah, T., & Rohdiana, D. (2018). Ekstraksi teh putih berbantu ultrasonik pada berbagai amplitudo. Jurnal Aplikasi Teknologi Pangan, 7(3), 111–116. https://doi.org/10.17728/jatp.2295

Wijaya, H., Novitasari, & Jubaidah, S. (2018). Perbandingan metode ekstraksi terhadap rendemen ekstrak daun rambui laut (Sonneratia caseolaris L. Engl). Jurnal Ilmiah Manuntung, 4(1), 79–83.

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Published

2025-09-10

How to Cite

Amaliya Bunga Dwiyanti, Devira Niken Putri Ferdinand, Mifta Dewi, Musa’adah Musa’adah, Noor Mila Wati, & Rima Hindriani. (2025). Review Metode Ekstraksi : Maserasi, Perkolasi, Infusa, Soxhlet, Refluks, Ultrasonic Assisted Extraction (UAE), dan Microwave Assisted Extraction (MAE). JURNAL RISET RUMPUN ILMU KEDOKTERAN, 4(3), 31–49. https://doi.org/10.55606/jurrike.v4i3.6465

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