Artikel Review: Perbandingan Sistem Matriks Hidrofilik dan Sistem Osmotik pada Tablet Lepas Terkendali

Abigail Yemima Christie; Amelia Defina Permatasari; Neza Ardelia Putri; Yola Asri Paramita; Hata Rianti Wasahua

doi:10.55606/innovation.v4i3.9257

Authors

Abigail Yemima Christie Universitas Negeri Semarang
Amelia Defina Permatasari Universitas Negeri Semarang
Neza Ardelia Putri Universitas Negeri Semarang
Yola Asri Paramita Universitas Negeri Semarang
Hata Rianti Wasahua Universitas Negeri Semarang

DOI:

https://doi.org/10.55606/innovation.v4i3.9257

Keywords:

Controlled-Release Tablet, Hydrophilic Matrix System, HPMC, Osmotic System, Zero-Order Release

Abstract

Controlled-release tablets are designed to release the active substance gradually in order to maintain stable drug plasma levels and reduce the frequency of drug administration. This study aims to compare hydrophilic matrix systems and osmotic systems in controlled-release tablet formulations using a literature review method. The results indicate that the hydrophilic matrix system operates through polymer hydration, diffusion, and matrix erosion mechanisms using polymers such as HPMC and Na CMC, though its release profile is influenced by gastrointestinal physiological conditions. The osmotic system produces a near zero-order release profile that is more consistent and independent of pH changes, despite requiring more complex manufacturing technology and higher production costs. Both systems demonstrate distinct advantages and limitations depending on the drug's solubility, dose uniformity requirements, and target release site. Furthermore, patient compliance and therapeutic efficacy are also key considerations in determining the most suitable formulation approach. Selection of the appropriate system should be tailored to the physicochemical properties of the active substance, therapeutic targets, and production efficiency considerations. A comprehensive understanding of these two systems is essential to support rational formulation decisions and to optimize therapeutic outcomes in pharmaceutical development.

Downloads

Download data is not yet available.

References

Almoshari, Y. (2022). Osmotic pump drug delivery systems: A comprehensive review. Pharmaceuticals, 15, 1430.

Anggrelia, T. P., Ginting, A. S., Rosyidah, Y. K. I., Istifadah, M., Agustino, F., Rahmawati, D., ... & Mubarak, M. F. (2024). Kajian penggunaan matriks pada formulasi tablet lepas lambat: Artikel review. Jurnal Anestesi, 2(3), 251–260. https://doi.org/10.59680/anestesi.v2i3.1249

Apriani, M., Oktavia, D. A., Rahmasari, D. A., Rahmawati, D., Zhihrotulwida, D., Ambari, Y., & Mubarak, M. F. (2025). Artikel review: Pengaruh penggunaan matriks pada tablet lepas lambat. Inovasi Kesehatan Global, 2(2), 96–106.

Armadani, V. A., Aisiyah, S., & Kuncahyo, I. (2020). Pengaruh matriks pektin dan HPMC K15M terhadap daya mengapung dan mengembang serta disolusi pada tablet floating verapamil HCl dengan metode factorial design. Journal of Pharmacy, 9(1), 27–35. https://doi.org/10.37013/jf.v9i1.100

Collet, J., & Moreton, C. (2002). Modified-release peroral dosage form. Dalam M. E. Aulton (Ed.), Pharmaceutics: The science of dosage form design (Edisi ke-2, hlm. 289–315). Churchill Livingstone.

Elvano, D. R., & Jafar, G. (2024). Optimasi sistem penghantaran obat antidiabetes oral melalui pompa osmotik untuk peningkatan bioavailabilitas dan efektivitas terapi. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu Keperawatan, Analis Kesehatan dan Farmasi, 24(2), 98–130.

Handiana, I. R., & Indriyati, W. (2016). Formulasi sediaan tablet lepas lambat teofilin dengan bahan matriks yang berkarakteristik hidrofilik: Review. Farmaka, 14(1), 136–141.

Hati, M. P. (2022). Pengaruh kombinasi matriks terhadap karakter tablet metformin HCl lepas lambat sistem floating effervescent. Pharmaceutical Journal of Indonesia, 7(2), 89–96. https://doi.org/10.21776/ub.pji.2022.007.02.3

Hendradi, E., Hariyadi, D. M., Purwanti, T., Rijal, M. A. S., Miatmoko, A., & Retnowati, D. (2023). Teknologi penghantaran obat. Airlangga University Press.

Khan, N. A., Khan, A., Ullah, R., Alotaibi, A., Ullah, R., & Haider, A. (2022). Preparation and characterization of hydrophilic polymer based sustained-release matrix tablets of a high dose hydrophobic drug. Polymers, 14, 1985.

Kushner, J., Lamba, M., Stock, T., Wang, R., Nemeth, M. A., Alvey, C., Chen, R., DeMatteo, V., & Blanchard, A. (2020). Development and validation of a level A in-vitro in-vivo correlation for tofacitinib modified-release tablets using extrudable core system osmotic delivery technology. European Journal of Pharmaceutical Sciences, 147, 105200. https://doi.org/10.1016/j.ejps.2019.105200

Martinah, & Noval. (2022). Floating system tablet ekstrak daun pepaya (Carica papaya L.) kombinasi matriks HPMC K4M dan Na CMC. Jurnal Farmasi & Sains Indonesia, 5(1), 20–29.

Mulia, R., & Fathurrahman, M. (2025). Tinjauan pustaka: Inovasi formulasi tablet lepas lambat untuk meningkatkan kepatuhan pasien. SENTRI: Jurnal Riset Ilmiah, 4(12), 4286–4294.

Nie, X., Wang, B., Hu, R., Lu, W., Chen, J., Liu, S., ... & Hao, H. (2020). Development and evaluation of controlled and simultaneous release of compound Danshen based on a novel colon-specific osmotic pump capsule. AAPS PharmSciTech, 21(2), 38. https://doi.org/10.1208/s12249-019-1603-9

Oktaviani, R. K., & Sukmawati, A. (2024). Evaluasi penggunaan berbagai macam polimer untuk matriks penghantaran obat secara transdermal. Journal of Integrative Natural Science, 1(1), 19–28.

Pertiwi, F. D. (2020). Formulasi dan uji disolusi terbanding tablet lepas lambat natrium diklofenak menggunakan Methocel K100M sebagai matriks. Indonesia Natural Research Pharmaceutical Journal, 5(2), 1–11. https://doi.org/10.52447/inspj.v5i2.1818

Purnamasari, N., Sutarna, T. H., Angraeni, W., Karin, A., Qotrunnada, D., & Alatas, F. (2023). Karakteristik fisik dan laju difusi in vitro sediaan transdermal patch domperidon menggunakan polimer turunan metil metakrilat-asam metakrilat. Jurnal Kartika Kimia, 6(2), 123–130. https://doi.org/10.26874/jkk.v6i2.235

Rahayu, F. E., Silvyana, A. E., Warti, L., Umar, S., & Rosaini, H. (2023). Solid dispersion system candesartan-cilexetil mannitol co-grinding method. PHARMACY: Jurnal Farmasi Indonesia, 83–90. https://doi.org/10.30595/pharmacy.v0i0.16667

Ramadhan, H. (2020). Formulasi dispersi padat Pentagamavunon-0 (PGV-0) dalam bentuk sediaan hidrogel dengan kombinasi basis polimer kitosan-agar-PVP. Jurnal Sains Farmasi & Klinis. https://doi.org/10.25077/jsfk.7.1.66-75.2020

Soliman, L., & Ibrahim, W. (2022). Effect of coating thickness and polyethylene glycol's molecular weight on diltiazem hydrochloride release from controlled porosity osmotic pump tablets. Research Journal of Pharmacy and Technology, 15(9), 4043–4047. https://doi.org/10.52711/0974-360X.2022.00678

Wibowo, D. N., & Sukmawati, A. (2022). Peningkatan laju pelarutan celecoxib menggunakan dispersi padat dengan polimer HPMC yang dikombinasi PVP dan PEG 6000. Jurnal Ilmu Kefarmasian Indonesia, 20(1), 81–86. https://doi.org/10.35814/jifi.v20i1.887

Zahra, M. R. A., Andini, V. P., Rusita, M. I., Santyas, A. A., Maharani, T. A., Wulandari, E. P., Rahmandani, F., Rahmawati, D., Zhihrotulwirda, D., Ambari, Y., & Mubarak, F. (2025). Formulasi dan evaluasi sediaan tablet lepas lambat. An-Najat: Jurnal Ilmu Farmasi dan Kesehatan, 3(2), 412–427. https://doi.org/10.59841/an-najat.v3i2.2716