Analisis Hubungan Kadar HbA1c dengan Kadar Glukosa Darah dan Kepatuhan Minum Obat pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Tilamuta, Kabupaten Boalemo, Provinsi Gorontalo

Nurhalmiyanti Nurhalmiyanti; Aloysia Ispriantari

doi:10.55606/jig.v4i2.8860

Authors

Nurhalmiyanti Nurhalmiyanti Institut Teknologi Sains dan Kesehatan RS dr. Soepraoen
Aloysia Ispriantari Institut Teknologi Sains dan Kesehatan RS dr. Soepraoen

DOI:

https://doi.org/10.55606/jig.v4i2.8860

Keywords:

Adherence, Blood Glucose, Glycemic Control, Hba1c, Type 2 Diabetes Mellitus

Abstract

Type 2 diabetes mellitus is a chronic condition marked by elevated blood glucose levels resulting from insulin resistance and decreased insulin secretion. Effective glycemic control is crucial to prevent complications, and HbA1c is commonly utilized as an indicator of long-term blood glucose levels. This study aimed to examine the relationship between HbA1c levels and blood glucose levels among patients with type 2 diabetes mellitus at Tilamuta Community Health Center, Boalemo Regency, Gorontalo Province. This study employed an analytical cross-sectional design using a total sampling method, involving 557 patients. Data were collected from laboratory records and analyzed through descriptive statistics, the Shapiro-Wilk test for normality, Spearman correlation, and chi-square test. The findings indicated that the average HbA1c level was 7.39%, while the mean blood glucose level was 205.85 mg/dL. A significant and very strong positive correlation was found between HbA1c and blood glucose levels (p=0.000; r=0.862). Furthermore, medication adherence showed a significant association with HbA1c status (p=0.000). These results underscore the role of HbA1c as a dependable marker for assessing glycemic control and highlight the importance of medication adherence in optimizing the management of type 2 diaType 2 diabetes mellitus is a chronic condition marked by elevated blood glucose levels resulting from insulin resistance and decreased insulin secretion. Effective glycemic control is crucial to prevent complications, and HbA1c is commonly utilized as an indicator of long-term blood glucose levels. This study aimed to examine the relationship between HbA1c levels and blood glucose levels among patients with type 2 diabetes mellitus at Tilamuta Community Health Center, Boalemo Regency, Gorontalo Province. This study employed an analytical cross-sectional design using a total sampling method, involving 557 patients. Data were collected from laboratory records and analyzed through descriptive statistics, the Shapiro-Wilk test for normality, Spearman correlation, and chi-square test. The findings indicated that the average HbA1c level was 7.39%, while the mean blood glucose level was 205.85 mg/dL. A significant and very strong positive correlation was found between HbA1c and blood glucose levels (p=0.000; r=0.862). Furthermore, medication adherence showed a significant association with HbA1c status (p=0.000). These results underscore the role of HbA1c as a dependable marker for assessing glycemic control and highlight the importance of medication adherence in optimizing the management of type 2 diabetes mellitus.betes mellitus.

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References

American Diabetes Association. (2021). Standards of medical care in diabetes—2021. Diabetes Care, 44(Suppl. 1), S1–S232. https://doi.org/10.2337/dc21-SINT

American Diabetes Association. (2022). Standards of medical care in diabetes—2022. Diabetes Care, 45(Suppl. 1), S1–S264. https://doi.org/10.2337/dc22-SINT

American Diabetes Association. (2023). Standards of care in diabetes—2023. Diabetes Care, 46(Suppl. 1), S1–S291. https://doi.org/10.2337/dc23-SINT

American Diabetes Association. (2024). Standards of care in diabetes—2024. Diabetes Care, 47(Suppl. 1), S1–S350.

Chatterjee, S., Khunti, K., & Davies, M. J. (2020). Type 2 diabetes. The Lancet, 395(10224), 2239–2251. https://doi.org/10.1016/S0140-6736(17)30058-2

Davies, M. J., et al. (2022). Management of hyperglycemia in type 2 diabetes. Diabetes Care, 45(11), 2753–2786. https://doi.org/10.2337/dci22-0034

Forouhi, N. G., & Wareham, N. J. (2021). Epidemiology of diabetes. Medicine, 49(2), 61–66.

García-Pérez, L. E., et al. (2021). Adherence to therapies in patients with type 2 diabetes. Diabetes Therapy, 12(1), 1–18.

International Diabetes Federation. (2021). IDF diabetes atlas (10th ed.). IDF.

Kementerian Kesehatan Republik Indonesia. (2023). Profil kesehatan Indonesia tahun 2023. Kemenkes RI.

Khunti, K., et al. (2021). Clinical inertia in people with type 2 diabetes. Diabetes Care, 44(7), 1610–1617.

Morisky, D. E., Ang, A., Krousel-Wood, M., & Ward, H. J. (2008). Predictive validity of a medication adherence measure in an outpatient setting. Journal of Clinical Hypertension, 10(5), 348–354. https://doi.org/10.1111/j.1751-7176.2008.07572.x

Nathan, D. M., et al. (2021). Translating the A1C assay into estimated average glucose values. Diabetes Care, 44(2), 434–438.

Polonsky, W. H., & Henry, R. R. (2021). Poor medication adherence in type 2 diabetes: Recognizing the scope of the problem and its key contributors. Patient Preference and Adherence, 15, 1299–1307. https://doi.org/10.2147/PPA.S278761

Powers, M. A., et al. (2020). Diabetes self-management education and support. Diabetes Care, 43(7), 1636–1649. https://doi.org/10.2337/dci20-0023

Riddle, M. C., et al. (2021). Glycemic targets in type 2 diabetes. Diabetes Care, 44(2), 258–266.

Saeedi, P., et al. (2021). Global and regional diabetes prevalence estimates. Diabetes Research and Clinical Practice, 183, 109119.

Saudek, C. D., & Brick, J. C. (2021). The clinical use of hemoglobin A1c. Journal of Diabetes Science and Technology, 15(3), 567–574.

Selvin, E., & Wang, D. (2021). HbA1c and risk of diabetes complications. The Lancet Diabetes & Endocrinology, 9(6), 341–342.

Sherwani, S. I., Khan, H. A., Ekhzaimy, A., Masood, A., & Sakharkar, M. K. (2020). Significance of HbA1c test in diagnosis and prognosis of diabetic patients. Biomarker Insights, 15, 1–9. https://doi.org/10.1177/1177271920950824

Zheng, Y., Ley, S. H., & Hu, F. B. (2020). Global aetiology and epidemiology of type 2 diabetes mellitus. Nature Reviews Endocrinology, 14(2), 88–98. https://doi.org/10.1038/nrendo.2017.151