Hubungan Kadar Eosinofil dengan Derajat Hipertrofi Konka melalui Pemeriksaan Darah pada Pasien Rawat Inap di Rumah Sakit Umum Cut Meutia Aceh Utara

Inna Dwi Raisa; Zubir Zubir; Baluqia Iskandar Putri

doi:10.55606/jig.v4i2.8857

Authors

Inna Dwi Raisa Universitas Malikussaleh
Zubir Zubir Universitas Malikussaleh
Baluqia Iskandar Putri Universitas Malikussaleh

DOI:

https://doi.org/10.55606/jig.v4i2.8857

Keywords:

Age, Eosinophil Levels, Gender, Turbinate Hypertrophy, Underlying Disease

Abstract

Turbinate hypertrophy is a condition characterized by abnormal enlargement of the nasal turbinate mucosa, which can lead to chronic nasal obstruction and decreased quality of life. This condition is associated with inflammatory processes in which eosinophils play a role as part of the immune response. This study aimed to determine the relationship between eosinophil levels and the degree of turbinate hypertrophy based on blood examination in hospitalized patients. This research used an observational analytic design with a cross-sectional approach involving 40 patients diagnosed with turbinate hypertrophy at Cut Meutia General Hospital, North Aceh. Data were obtained from medical records, including patient characteristics, eosinophil levels, and the degree of turbinate hypertrophy. The results showed that most patients were aged 17–25 years, predominantly female, and commonly had non-allergic underlying conditions. The majority of patients had normal eosinophil levels (80%), while most cases were classified as grade III turbinate hypertrophy (65%). Statistical analysis using Fisher’s Exact Test demonstrated no significant relationship between eosinophil levels and the degree of turbinate hypertrophy (p>0.05). These findings suggest that eosinophil levels may not be a reliable indicator in assessing the severity of turbinate hypertrophy, particularly in patients with non-allergic conditions. This study highlights the need to consider other contributing factors in the evaluation and management of turbinate hypertrophy to improve diagnostic accuracy and treatment outcomes.

Downloads

Download data is not yet available.

References

Bousquet, J., Schünemann, H. J., Togias, A., Bachert, C., Erhola, M., Hellings, P. W., … & Zuberbier, T. (2020). Next-generation ARIA care pathways for rhinitis and asthma. Allergy, 75(1), 20-30. https://doi.org/10.1111/all.13905

Cho, S. H., Kim, K. R., & Lee, S. H. (2020). Relationship between eosinophil levels and nasal obstruction severity. Clinical and Experimental Otorhinolaryngology, 13(2), 150-156. https://doi.org/10.21053/ceo.2019.01023

Dahlan, M. S. (2014). Statistik untuk kedokteran dan kesehatan (6th ed.). Jakarta: Salemba Medika.

Fokkens, W. J., Lund, V. J., Hopkins, C., Hellings, P. W., Kern, R., Reitsma, S., … & Bachert, C. (2020). European position paper on rhinosinusitis and nasal polyps 2020. Rhinology, 58(Suppl S29), 1-464. https://doi.org/10.4193/Rhin20.600

Han, J. K., Stringer, S. P., & Rosenfeld, R. M. (2021). Clinical consensus statement: Diagnosis and management of nasal obstruction. Otolaryngology-Head and Neck Surgery, 164(2), 235-247. https://doi.org/10.1177/0194599820962330

Hastono, S. P. (2017). Analisis data pada bidang kesehatan. Jakarta: Rajawali Pers.

Kim, D. Y., Kim, S. W., & Cho, S. H. (2017). Association between eosinophil count and turbinate hypertrophy severity. American Journal of Rhinology & Allergy, 31(4), 256-261. https://doi.org/10.2500/ajra.2017.31.4450

Kim, Y. H., Park, S. K., & Lee, J. H. (2018). No association between eosinophil levels and nasal obstruction severity. International Forum of Allergy & Rhinology, 8(3), 310-315. https://doi.org/10.1002/alr.22050

Krouse, J. H., & Brown, R. W. (2020). Allergy and nasal airway disease. Immunology and Allergy Clinics of North America, 40(2), 231-245. https://doi.org/10.1016/j.iac.2020.01.004

Munir, M., Siregar, N. C., & Putra, A. (2021). Prevalence of turbinate hypertrophy in Indonesian population. Indonesian Journal of Otorhinolaryngology, 51(1), 45-50.

Notoatmodjo, S. (2018). Metodologi penelitian kesehatan. Jakarta: Rineka Cipta.

Orlandi, R. R., Kingdom, T. T., Hwang, P. H., Smith, T. L., Alt, J. A., Baroody, F. M., … & Patel, Z. M. (2021). International consensus statement on allergy and rhinology. International Forum of Allergy & Rhinology, 11(3), 213-739. https://doi.org/10.1002/alr.22741

Rothenberg, M. E., & Hogan, S. P. (2020). The eosinophil. Annual Review of Immunology, 38, 281-306. https://doi.org/10.1146/annurev-immunol-071719-125028

Setiadi. (2013). Konsep dan praktik penulisan riset keperawatan. Yogyakarta: Graha Ilmu.

Soepardi, E. A., Iskandar, N., & Bashiruddin, J. (2012). Buku ajar ilmu kesehatan THT-KL. Jakarta: FKUI.

Stevens, W. W., Peters, A. T., Hirsch, A. G., Nordberg, C. M., Schwartz, B. S., Mercer, D. G., … & Grammer, L. C. (2021). Clinical characteristics of patients with chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 147(2), 567-575. https://doi.org/10.1016/j.jaci.2020.06.041

Tan, B. K., Li, Q. Z., Suh, L., & Kato, A. (2020). Evidence for intranasal inflammation in turbinate hypertrophy. Journal of Allergy and Clinical Immunology, 145(3), 873-882. https://doi.org/10.1016/j.jaci.2019.11.021

Wang, X., Zhang, N., Bo, M., Holtappels, G., Zheng, M., Lou, H., … & Bachert, C. (2021). Diversity of inflammatory endotypes in chronic rhinosinusitis. Allergy, 76(7), 1983-1995. https://doi.org/10.1111/all.14660

Whittaker, E. (2015). Turbinate hypertrophy and nasal obstruction. Medscape.

Zhang, Y., Gevaert, E., Lou, H., Wang, X., Zhang, L., Bachert, C., & Zhang, N. (2022). Chronic rhinosinusitis and inflammatory pathways. Frontiers in Immunology, 13, 812-820. https://doi.org/10.3389/fimmu.2022.812345