Laporan Kasus: Dengue Fever dengan Warning sign dan Diare Akut pada Bayi
DOI:
https://doi.org/10.55606/jig.v4i2.8833Keywords:
Diarrhea, Dengue, Fever, Infant, Warning SignAbstract
Introduction: Dengue fever is a viral infection transmitted through the bite of infected female Aedes aegypti mosquito, caused by four dengue virus serotypes (DEN-1 to DEN-4), with clinical manifestations ranging from asymptomatic to severe disease and may be accompanied by warning sign. Concurrent infections, such as acute diarrhea, may worsen outcomes, particularly in children. Case Report: A nine-month-old female presented with a five-day history of intermittent fever and watery diarrhea. Additional symptoms included vomiting, lethargy, and decreased appetite. Physical examination showed a moderately ill appearance and sunken eyes. Laboratory findings revealed positive dengue IgM, negative dengue IgG, thrombocytopenia (22,000/µL), and hematocrit of 37%. The patient was diagnosed with dengue fever with warning sign and acute diarrhea. Management included intravenous crystalloid fluids, antipyretics, antibiotics, H2 receptor antagonists, and zinc supplementation. Conclusion: Dengue with warning sign and concurrent acute diarrhea in children increases the risk of morbidity and mortality. Early and appropriate management is essential to prevent disease progression and improve clinical outcomes.
Downloads
References
Ajlan, B. A., Alafif, M. M., Alawi, M. M., & Akbar, N. A. (2019). Assessment of the new World Health Organization's dengue classification for predicting severity of illness and level of healthcare required. PLOS Neglected Tropical Diseases, 1–16. https://doi.org/10.1101/516229
Akram, A., Akram, L., Ghosh, U. K., Abiduzzaman, M. F., & Rahman, S. (2023). Gastrointestinal manifestations of dengue fever among children: A multicenter cross-sectional study in Bangladesh. Bangladesh Journal of Medical Microbiology, 17(2), 66–70. https://doi.org/10.3329/bjmm.v17i2.69294
Deng, J., Zhang, H., Wang, Y., Liu, Q., Du, M., Yan, W., Qin, C., Zhang, S., Chen, W., Zhou, L., & Liu, M. (2024). Global, regional, and national burden of dengue infection in children and adolescents: An analysis of the Global Burden of Disease Study 2021. EClinicalMedicine, 78, 1–15. https://doi.org/10.1016/j.eclinm.2024.102943
Dutta, A., Bakari, M., Sc, M., Deb, S., & Ph, D. (2020). Lower-dose zinc for childhood diarrhea: A randomized, multicenter trial. The New England Journal of Medicine, 1231–1241. https://doi.org/10.1056/NEJMoa1915905
Faridah, I. N., Dania, H., Chen, Y.-H., Supadmi, W., Purwanto, Djaka, B., Heriyanto, M. J., Aufa, M. A., Chang, W., & Perwitasari, D. A. (2022). Dynamic changes of platelet and factors related to dengue hemorrhagic fever: A retrospective study in Indonesia. Diagnostics, 12(4), 1–12. https://doi.org/10.3390/diagnostics12040950
Guarino, A., Aguilar, J., Berkley, J., Broekaert, I., & Vazquez, R. (2022). Acute gastroenteritis in children of the world: What needs to be done? J Pediatr Gastroenterol Nutr, 70(5), 694–701. https://doi.org/10.1097/MPG.0000000000002669
Hartman, S., Brown, E., Loomis, E., & Russell, H. A. (2019). Gastroenteritis in children. American Family Physician, 99(3), 159–165.
Hasan, M. J., Islam, M., Tabassum, T., Khan, M., & Islam, K. (2025). Clinical and epidemiological characteristics of the dengue outbreak of 2024: A multicenter observation from Bangladesh. Tropical Medicine and Health, 1–11. https://doi.org/10.1186/s41182-025-00691-y
Henriques, S., Ana, P., Moreira, P., Luiz, F., Tita, C., Guilherme, N., & Varino, O. (2026). Clinical, serological, and molecular profile of dengue patients with warning signs during the 2024 outbreak in Belo Horizonte, Brazil. Journal of Medical Virology, 1–13. https://doi.org/10.1002/jmv.70805
IDAI. (2016). Kebutuhan air pada anak sehat. Kebutuhan air pada anak sehat.
Jha, A. K., Shah, S., Das, B., & Das, S. K. (2023). Clinical profile of acute gastroenteritis in children at a tertiary center. Journal of National Medical College, 8(1), 11–16. https://doi.org/10.3126/medphoenix.v8i1.56907
Jiménez-Jiménez, A. B., Galán-Sánchez, F., & Hortelano, M. G. (2025). Acute infectious gastroenteritis in childhood: The role of rapid multiplex molecular syndromic panels in diagnosis and clinical management. Rev Esp Quimioter, 38(4), 258–277. https://doi.org/10.37201/req/026.2025
Kemenkes RI. (2021). Pedoman Nasional Pelayanan Kedokteran: Tata Laksana Infeksi Dengue Anak dan Remaja.
Leung, A. K. C., & Hon, K. L. (2021). Paediatrics: How to manage viral gastroenteritis. Drugs in Context, 1–11. https://doi.org/10.7573/dic.2020-11-7
Liang, D., Wang, L., Liu, S., Li, S., Zhou, X., Xiao, Y., Zhong, P., Chen, Y., Wang, C., Xu, S., Su, J., Luo, Z., Ke, C., & Lai, Y. (2024). Global incidence of diarrheal diseases - An update using an interpretable predictive model based on XGBoost and SHAP: A systematic analysis. Nutrients. https://doi.org/10.3390/nu16183217
Mikhael, K., Husada, D., & Lestari, P. (2022). Profile of dengue fever complication in infants at a tertiary referral hospital in East Java, Indonesia. Biomolecular and Health Science Journal, 5(1), 11–15. https://doi.org/10.20473/bhsj.v5i1.34827
Mutanabbi, M., & Bornee, F. A. (2024). Changing trend of dengue fever in children. Paediatric Nephrology Journal of Bangladesh, 9(1), 1–3. https://doi.org/10.4103/pnjb.pnjb_1_24
Ng, D. H. L., Wong, J. G. X., Thein, T., & Leo, Y. (2016). The significance of prolonged and saddleback fever in hospitalized adult dengue. PLOS ONE, 1–9. https://doi.org/10.1371/journal.pone.0167025
Parveen, R., Masud, A. H., Kabir, F. L., Rahman, M., & Hoque, M. (2025). Prolonged and saddleback fever in children with dengue: Prevalence and severity correlation in a pediatric intensive care unit. Journal of Rangpur Medical College Expanded, 10(2), 4–10. https://doi.org/10.3329/jrpmc.v10i2.85671
Prihandono, D. S., Pramesti, S. R., Hartini, S., & Wahyunie, S. (2024). Gambaran hasil IgM dan IgG pasien demam berdarah dengue anak di RSUD Inche Abdoel Moeis pada tahun 2023. Mahakam Medical Laboratory Technology Journal, 4(2), 86–95.
Tejo, A. M., Hamasaki, D. T., Menezes, L. M., & Ho, Y. (2024). Severe dengue in the intensive care unit. Journal of Intensive Medicine, 4(July 2023), 16–33. https://doi.org/10.1016/j.jointm.2023.07.007
World Health Organization (WHO). (2022). National guideline for clinical management of dengue. World Health Organization. https://cdn.who.int/media/docs/default-source/2021-dha-docs/5_national-clinical-guideline-of-dengue-timor-leste_clean_final-12-dec-2022.pdf?sfvrsn=e80bf9cd_1
World Health Organization (WHO). (2025). WHO guidelines for clinical management of arboviral diseases: Dengue, chikungunya, Zika and yellow fever. World Health Organization.
Zhang, Y., Abudunaibi, B., Zhao, Y., Zhang, D., Chu, Y., Lei, S., Gu, X., Lao, X., Wu, X., Yao, W., Chen, Y., & Tong, F. (2024). Dynamics and efficacy: A comprehensive evaluation of the advanced dengue fever surveillance and early warning system in Ningbo. Risk Management and Healthcare Policy, 1947–1955. https://doi.org/10.2147/RMHP.S470237
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Jurnal Ilmu Kesehatan dan Gizi

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.







