Pengaruh Pemberian Naringenin terhadap Penghambatan Pertumbuhan Sel Kanker : Literature Review
DOI:
https://doi.org/10.55606/jig.v3i2.4363Keywords:
Cancer cell, Naringenin, Proliferation, ViabilityAbstract
Cancer is a disease that results from changes in cell function and structure, which leads to abnormal and uncontrolled cell division. These changes can affect gene expression, leading to uncontrolled cell proliferation, invasion, and metastasis to other tissues and organs. An alternative to cancer treatment can be done by administering phytochemical compounds, one of which is naringenin. This study aims to determine the effect of naringenin on the growth of cancer cells. The method used in this study is a literature review of in vitro experimental articles published in the last ten years and obtained the results of 7 articles. The study results showed that naringenin can inhibit the proliferation, migration, and invasion of cancer cells through several mechanisms. In addition, naringenin has been shown to induce apoptosis and alter the morphology of cancer cells. It can be concluded that naringenin has great potential as an alternative therapy for cancer.
Downloads
References
Alfiani, D., Putri, M. P., & Widayanti, W. (2022). Literature study: Obesitas sebagai faktor risiko pada kanker payudara triple negative. Bandung Conference Series: Medical Science, 2(1), 326–329. https://doi.org/10.29313/bcsms.v2i1.760
Arifianti, L., Studiawan, H., & Megawati, L. (2014). Uji aktivitas ekstrak biji sirsak (Annona muricata L.) terhadap sel kanker mamalia secara in vitro. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 1(2), 63–66.
Chang, T. M., Chi, M. C., Chiang, Y. C., Lin, C. M., Fang, M. L., Lee, C. W., Liu, J. F., & Kou, Y. R. (2024). Promotion of ROS-mediated apoptosis, G2/M arrest, and autophagy by naringenin in non-small cell lung cancer. International Journal of Biological Sciences, 20(3), 1093–1109. https://doi.org/10.7150/ijbs.85443
Han, K. Y., Chen, P. N., Hong, M. C., Hseu, Y. C., Chen, K. M., Hsu, L. S., & Chen, W. J. (2018). Naringenin attenuated prostate cancer invasion via reversal of epithelial–to–mesenchymal transition and inhibited uPA activity. Anticancer Research, 38(12), 6753–6758. https://doi.org/10.21873/anticanres.13045
Lin, C., Zeng, Z., Lin, Y., Wang, P., Cao, D., Xie, K., Luo, Y., Yang, H., Yang, J., Wang, W., Luo, L. J., Lin, H., Chen, H., Zhao, Y., Shi, Y., Gao, Z., Liu, H., & Liu, S. L. (2022). Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota. Phytomedicine, 106, 154401. https://doi.org/10.1016/j.phymed.2022.154401
Lozano-Herrera, S. J., Luna-Bárcenas, G., Guevara-González, R. G., Campos-Vega, R., Solís-Sáinz, J. C., Hernández-Puga, A. G., & Vergara-Castañeda, H. A. (2022). Fermentation extract of naringenin increases the expression of estrogenic receptor β and modulates genes related to the p53 signalling pathway, miR-200c and miR-141 in human colon cancer cells exposed to BPA. Molecules, 27(19), Article 6588. https://doi.org/10.3390/molecules27196588
Memariani, Z., Abbas, S. Q., ul Hassan, S. S., Ahmadi, A., & Chabra, A. (2021). Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review. Pharmacological Research, 171, 105264. https://doi.org/10.1016/j.phrs.2020.105264
Motallebi, M., Bhia, M., Rajani, H. F., Bhia, I., Tabarraei, H., Mohammadkhani, N., Pereira-Silva, M., Kasaii, M. S., Nouri-Majd, S., Mueller, A. L., Veiga, F. J. B., Paiva-Santos, A. C., & Shakibaei, M. (2022). Naringenin: A potential flavonoid phytochemical for cancer therapy. Life Sciences, 305, 120752. https://doi.org/10.1016/j.lfs.2022.120752
Salehi, B., Fokou, P. V. T., Sharifi-Rad, M., Zucca, P., Pezzani, R., Martins, N., & Sharifi-Rad, J. (2019). The therapeutic potential of naringenin: A review of clinical trials. Pharmaceuticals, 12(1), Article 11. https://doi.org/10.3390/ph12010011
Stabrauskiene, J., Kopustinskiene, D. M., Lazauskas, R., & Bernatoniene, J. (2022). Naringin and naringenin: Their mechanisms of action and the potential anticancer activities. Biomedicines, 10(7), Article 1686. https://doi.org/10.3390/biomedicines10071686
Wang, X., Zhang, X., Liu, Z., Zhao, N., Li, X., Su, P., Zheng, G., Zhang, X., Wang, H., & Zhang, Y. (2024). Naringenin nanoparticles targeting cyclin B1 suppress the progression of rheumatoid arthritis-associated lung cancer by inhibiting fibroblast-to-myofibroblast transition. International Journal of Biochemistry and Cell Biology, 169, 106557. https://doi.org/10.1016/j.biocel.2024.106557
Widyanto, R. M., Putri, J. A., Rahmi, Y., Proborini, W. D., & Utomo, B. (2020). Aktivitas antioksidan dan sitotoksisitas in vitro ekstrak metanol buah nanas (Ananas comosus) pada sel kanker payudara T-47D. Jurnal Pangan dan Agroindustri, 8(2), 95–103. https://doi.org/10.21776/ub.jpa.2020.008.02.5
Xiong, H., Chen, Z., Lin, B., Xie, B., Liu, X., Chen, C., Li, Z., Jia, Y., Wu, Z., Yang, M., Jia, Y., Wang, L., Zhou, J., & Meng, X. (2022). Naringenin regulates FKBP4/NR3C1/NRF2 axis in autophagy and proliferation of breast cancer and differentiation and maturation of dendritic cell. Frontiers in Immunology, 12, Article 745111. https://doi.org/10.3389/fimmu.2021.745111
Yousuf, M., Shamsi, A., Khan, S., Khan, P., Shahwan, M., Elasbali, A. M., Haque, Q. M. R., & Hassan, M. I. (2022). Naringenin as a potential inhibitor of human cyclin-dependent kinase 6: Molecular and structural insights into anti-cancer therapeutics. International Journal of Biological Macromolecules, 213, 944–954. https://doi.org/10.1016/j.ijbiomac.2022.06.013
Zhou, J., Li, H., Wu, B., Zhu, L., Huang, Q., Guo, Z., He, Q., Wang, L., Peng, X., & Guo, T. (2024). Network pharmacology combined with experimental verification to explore the potential mechanism of naringenin in the treatment of cervical cancer. Scientific Reports, 14(1), Article 52413. https://doi.org/10.1038/s41598-024-52413-9
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Jurnal Ilmu Kesehatan dan Gizi
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
