Dampak Positif Fitokimia Zeaxanthine Terhadap Kesehatan Mata dan Penyakit Degeneratif
DOI:
https://doi.org/10.55606/jig.v3i2.3607Keywords:
Zeaxanthin, eye health, degenerative diseasesAbstract
Degenerative diseases such as diabetes mellitus are related to eye health. This is because the blood vessels in the retina can be an indication when someone is experiencing a pathological abnormality. Zeaxanthine as a type of phytochemical which is included in the carotenoid group or derivative has a role in preventing eye damage, especially to the retina and several degenerative diseases. This research uses a literature review method by retrieving scientific articles online on trusted pages such as PubMed, Science Direct and Crossmark. The aim of this research is to determine the effect and benefits of consuming zeaxanthin either in the form of consuming food sources of zeaxanthin directly or through supplements on eye health and degenerative diseases. The results of this study show the positive role of zeaxanthin in maintaining eye health and preventing nearsightedness, retinal damage and cataracts. Meanwhile, the relationship between zeaxanthin intake and the prevention of degenerative diseases has been explained in all scientific articles used in this research.
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Age-Related Eye Disease Study 2 (AREDS2) Research Group, Chew, E. Y., Clemons, T. E., Sangiovanni, J. P., Danis, R. P., Ferris, F. L., 3rd, Elman, M. J., Antoszyk, A. N., Ruby, A. J., Orth, D., Bressler, S. B., Fish, G. E., Hubbard, G. B., Klein, M. L., Chandra, S. R., Blodi, B. A., Domalpally, A., Friberg, T., Wong, W. T., Rosenfeld, P. J., … Sperduto, R. D. (2014). Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3. JAMA ophthalmology, 132(2), 142–149.
https://doi.org/10.1001/jamaophthalmol.2013.7376.
Azami, B. N. L., & Sun, M. (2019). Zeaxanthin Dipalmitate in the Treatment of Liver Disease. Evidence-based complementary and alternative medicine : eCAM, 2019, 1475163. https://doi.org/10.1155/2019/1475163
Demmig-Adams, B., López-Pozo, M., Stewart, J. J., & Adams III, W. W. (2020). Zeaxanthin and lutein: Photoprotectors, anti-inflammatories, and brain food. Molecules, 25(16), 3607.
Demmig-Adams, B., Polutchko, S. K., & Adams III, W. W. (2022). Structure-function-environment relationship of the isomers zeaxanthin and lutein. Photochem, 2(2), 308-325.
Eisenhauer, B., Natoli, S., Liew, G., & Flood, V. M. (2017). Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection. Nutrients, 9(2), 120.
https://doi.org/10.3390/nu9020120
Fatihaturahmi, F., Yuliana, Y., & Yulastri, A. (2023). Literature Review: Penyakit Degeneratif: Penyebab, Akibat, Pencegahan Dan Penanggulangan. JGK: Jurnal Gizi dan Kesehatan, 3(1), 63-72.
Fretes, H., Susanto, A. B., Prasetyo, B., & Limantara, L. (2012). Karotenoid dari Makroalgae dan Mikroalgae: Potensi Kesehatan Aplikasi dan Bioteknologi. Jurnal Teknologi dan Industri Pangan, 23(2), 221.
Gammone, M. A., Riccioni, G., & D'Orazio, N. (2015). Carotenoids: potential allies of cardiovascular health?. Food & nutrition research, 59, 26762. https://doi.org/10.3402/fnr.v59.26762
Jia, Y. P., Sun, L., Yu, H. S., Liang, L. P., Li, W., Ding, H., ... & Zhang, L. J. (2017). The pharmacological effects of lutein and zeaxanthin on visual disorders and cognition diseases. Molecules, 22(4), 610.
Johnson, E. J. (2014). Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutrition reviews, 72(9), 605-612.
Li, X., Holt, R. R., Keen, C. L., Morse, L. S., Zivkovic, A. M., Yiu, G., & Hackman, R. M. (2023). Potential roles of dietary zeaxanthin and lutein in macular health and function. Nutrition reviews, 81(6), 670-683.
Lopresti, A. L., Smith, S. J., & Drummond, P. D. (2022). The Effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported mild cognitive complaints: A randomized, double-blind, placebo-controlled study. Frontiers in Nutrition, 9, 843512.
Ma, L., Yan, S. F., Huang, Y. M., Lu, X. R., Qian, F., Pang, H. L., Xu, X. R., Zou, Z. Y., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., Dou, H. L., & Lin, X. M. (2012). Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age related macular degeneration. Ophthalmology, 119(11), 2290–2297. https://doi.org/10.1016/j.ophtha.2012.06.014
Mewborn, C. M., Terry, D. P., Renzi-Hammond, L. M., Hammond, B. R., & Miller, L. S. (2018). Relation of retinal and serum lutein and zeaxanthin to white matter integrity in older adults: A diffusion tensor imaging study. Archives of Clinical Neuropsychology, 33(7), 861-874.
Mrowicka, M., Mrowicki, J., Kucharska, E., & Majsterek, I. (2022). Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration-Neurodegenerative Disease. Nutrients, 14(4), 827.
https://doi.org/10.3390/nu14040827
Murillo, A. G., Hu, S., & Fernandez, M. L. (2019). Zeaxanthin: Metabolism, properties, and antioxidant protection of eyes, heart, liver, and skin. Antioxidants, 8(9), 390.
Parekh, R., Hammond, B.R. & Chandradhara, D.(2024). Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study. Adv Ther 41, 1496–1511.
https://doi.org/10.1007/s12325-024-02785-1
Roberts, J. E., & Dennison, J. (2015). The Photobiology of Lutein and Zeaxanthin in the Eye. Journal of ophthalmology, 2015, 687173.
https://doi.org/10.1155/2015/687173
Tuzcu, M., Orhan, C., Muz, O. E., Sahin, N., Juturu, V., & Sahin, K. (2017). Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model. BMC ophthalmology, 17, 1-9.
Wangko, S. (2013). Histofisiologi Retina. Jurnal Biomedik: JBM, 5(3).
Wang, Y., Chung, S. J., McCullough, M. L., Song, W. O., Fernandez, M. L., Koo, S. I., & Chun, O. K. (2014). Dietary carotenoids are associated with cardiovascular disease risk biomarkers mediated by serum carotenoid concentrations. The Journal of nutrition, 144(7), 1067-1074.
Wilson, L. M., Tharmarajah, S., Jia, Y., Semba, R. D., Schaumberg, D. A., & Robinson, K. A. (2021). The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis. Advances in nutrition (Bethesda, Md.), 12(6), 2244–2254.
https://doi.org/10.1093/advances/nmab071
Xiao, J., Wang, J., Xing, F., Han, T., Jiao, R., Liong, E. C., ... & Tipoe, G. L. (2014). Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway. PLoS One, 9(4), e95214.
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