Association between Dietary Omega-3 Intake and Dry Eye Syndrome in Adults: A Cross-Sectional Study

Authors

  • Anisa Henintya Rizki Putri Universitas Trisakti
  • Husnun Amalia Universitas Trisakti

DOI:

https://doi.org/10.55606/jurrikes.v5i2.8985

Keywords:

Dry Eye Syndrome, Nutritional Intake, Ocular Surface, Omega-3 Fatty Acids, Working Adults

Abstract

Dry eye syndrome (DES) is a common ocular surface disorder that can impair visual function and quality of life, particularly among working-age adults. Although DES has a multifactorial etiology, nutritional factors, such as omega-3 fatty acid intake, have been suggested to modulate inflammation associated with the condition. This study aimed to investigate the association between dietary omega-3 intake and dry eye syndrome in adults. This cross-sectional analytical observational study included 88 participants aged 15-59 years. Participants were selected using consecutive non-random sampling and assessed with a Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) to estimate omega-3 intake, while dry eye symptoms were evaluated using the Ocular Surface Disease Index (OSDI). Statistical analyses included chi-square and Fisher’s exact test. The results showed that 51.1% of the participants had insufficient omega-3 intake (<250 mg/day), and 29.5% experienced dry eye syndrome. No statistically significant association was found between sex or age and DES occurrence. However, a significant association was found between omega-3 intake and dry eye syndrome (p < 0.001), with individuals consuming insufficient omega-3 having a substantially higher risk of developing DES. These findings suggest that adequate omega-3 intake may play a protective role in dry eye syndrome. This study underscores the potential of dietary interventions as a strategy for preventing and managing DES.

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References

Alqurashi, A., Almaghrabi, H., Alahmadi, M., Alotaibi, A., Alotaibi, B., Jastaniah, A., ... Khojah, A. (2024). The severity of dry eye symptoms and risk factors among university students in Saudi Arabia: A cross-sectional study. Scientific Reports, 14(1), 15149. https://doi.org/10.1038/s41598-024-65297-6

Arisjulyanto, D., & Siregar, N. S. A. (2024). The impact of education on TB prevention in stunted children in the working area of the Kosiwo Health Center, Kepulauan Yapen Regency. International Journal of Health and Medicine, 2(1), 30–38. https://doi.org/10.62951/ijhm.v2i1.201

Badan Pusat Statistik. (2021). Hasil sensus penduduk 2020. Badan Pusat Statistik. https://bps.go.id/pressrelease.html

Barabino, S., Horwath-Winter, J., Messmer, E. M., Rolando, M., Aragona, P., & Kinoshita, S. (2017). The role of systemic and topical fatty acids for dry eye treatment. Progress in Retinal and Eye Research, 61, 23–34. https://doi.org/10.1016/j.preteyeres.2017.05.003

Bhargava, R., Kumar, P., Phogat, H., et al. (2015). Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye. Contact Lens and Anterior Eye, 38(3), 206–210. https://doi.org/10.1016/j.clae.2015.01.007

Bron, A. J., de Paiva, C. S., Chauhan, S. K., Bonini, S., Gabison, E. E., Jain, S., ... Sullivan, D. A. (2017). TFOS DEWS II pathophysiology report. The Ocular Surface, 15(3), 438–510. https://doi.org/10.1016/j.jtos.2017.05.011

Craig, J. P., Nichols, K. K., Akpek, E. K., Caffery, B., Dua, H. S., Joo, C.-K., ... Stapleton, F. (2017). TFOS DEWS II definition and classification report. The Ocular Surface, 15(3), 276–283. https://doi.org/10.1016/j.jtos.2017.05.008

Dry Eye Assessment and Management Study Research Group, Asbell, P. A., Maguire, M. G., Pistilli, M., Ying, G., Szczotka-Flynn, L. B., ... Shtein, R. M. (2018). n-3 fatty acid supplementation for the treatment of dry eye disease. The New England Journal of Medicine, 378(18), 1681–1690. https://doi.org/10.1056/NEJMoa1709691

Epitropoulos, A. T., Donnenfeld, E. D., Shah, Z. A., Holland, E. J., Gross, M., Faulkner, W. J., ... Perry, H. D. (2016). Effect of oral re-esterified omega-3 nutritional supplementation on dry eyes. Cornea, 35(9), 1185–1191. https://doi.org/10.1097/ICO.0000000000000940

Harrell, C. R., Feulner, L., Djonov, V., Pavlovic, D., & Volarevic, V. (2023). The molecular mechanisms responsible for tear hyperosmolarity-induced pathological changes in the eyes of dry eye disease patients. Cells, 12(23), 2755. https://doi.org/10.3390/cells12232755

Hyon, J.-Y., & Han, S.-B. (2021). The protective effect of polyunsaturated fatty acids against dry eye disease: A literature review. Applied Sciences, 11(10), 4519. https://doi.org/10.3390/app11104519

Lemp, M. A. (2007). Advances in understanding and managing dry eye disease. American Journal of Ophthalmology, 146(3), 350–356. https://doi.org/10.1016/j.ajo.2008.05.016

Mohamed, H. B., Abd El-Hamid, B. N., Fathalla, D., & Fouad, E. A. (2022). Current trends in pharmaceutical treatment of dry eye disease: A review. European Journal of Pharmaceutical Sciences, 175, 106206. https://doi.org/10.1016/j.ejps.2022.106206

Nelson, J. D., Shimazaki, J., Benitez-del-Castillo, J. M., Craig, J. P., McCulley, J. P., Den, S., & Foulks, G. N. (2011). The international workshop on meibomian gland dysfunction: Report of the definition and classification subcommittee. Investigative Ophthalmology & Visual Science, 52(4), 1930–1937. https://doi.org/10.1167/iovs.10-6997b

Pang, H. M., Yau, M. Q., Aftab, R. A., Sellappans, R., & Tan, B. K. (2025). Prevalence, severity, and treatment of dry eye disease among patients presenting at community pharmacies in Klang Valley, Malaysia. Pharmacy Practice, 23(3), 1–13. https://doi.org/10.18549/PharmPract.2025.3.3258

Papas, E. B. (2021). The global prevalence of dry eye disease: A Bayesian view. Ophthalmic and Physiological Optics, 41(6), 1254–1266. https://doi.org/10.1111/opo.12888

Schaumberg, D. A., Dana, R., Buring, J. E., & Sullivan, D. A. (2009). Prevalence of dry eye disease among US men: Estimates from the Physicians’ Health Studies. Archives of Ophthalmology, 127(6), 763–768. https://doi.org/10.1001/archophthalmol.2009.103

Scientific opinion on the tolerable upper intake level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA). (2012). EFSA Journal, 10(7). https://doi.org/10.2903/j.efsa.2012.2815

Stapleton, F., Alves, M., Bunya, V. Y., Jalbert, I., Lekhanont, K., Malet, F., ... Jones, L. (2017). TFOS DEWS II epidemiology report. The Ocular Surface, 15(3), 334–365. https://doi.org/10.1016/j.jtos.2017.05.003

Wolffsohn, J. S., Arita, R., Chalmers, R., Djalilian, A., Dogru, M., Dumbleton, K., ... Craig, J. P. (2017). TFOS DEWS II diagnostic methodology report. The Ocular Surface, 15(3), 539–574. https://doi.org/10.1016/j.jtos.2017.05.001

Zhang, A. C., Singh, S., Craig, J. P., & Downie, L. E. (2020). Omega-3 fatty acids and eye health: Opinions and self-reported practice behaviors of optometrists in Australia and New Zealand. Nutrients, 12(4), 1179. https://doi.org/10.3390/nu12041179

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Published

2026-05-13

How to Cite

Anisa Henintya Rizki Putri, & Husnun Amalia. (2026). Association between Dietary Omega-3 Intake and Dry Eye Syndrome in Adults: A Cross-Sectional Study. JURNAL RISET RUMPUN ILMU KESEHATAN, 5(2), 186–193. https://doi.org/10.55606/jurrikes.v5i2.8985