Studi Literatur : Analisis Efek Toksik pada Kasus Bunuh Diri Akibat Penggunaan Amfetamin
DOI:
https://doi.org/10.55606/jurrikes.v4i2.5769Keywords:
Amphetamines, Suicide, Toxic EffectsAbstract
This study aims to analyze the toxic effects brought about by amphetamine use and its association with suicides. Suicide is an act of ending one's own life that is often associated with mental health disorders and life pressures. Amphetamines are classified as Class II psychotropic drugs that have a strong stimulant effect on the central nervous system, causing changes in behavior and mental activity, including hallucinations, thought disorders, and emotional changes. This study was conducted based on a literature review, identifying and analyzing various suicide cases involving amphetamine use through relevant literature. The results of the literature analysis indicate that amphetamine use significantly increases the risk of suicidal behavior, which can affect neurotransmitters, potentially triggering psychosis, nerve damage, and cardiovascular issues. Chronic use leads to dependence, cognitive impairment.
Downloads
References
Al-Asmari, A., Al-Solami, F. D., Al-Zahrani, A. E., & Zughaibi, T. A. (2022). Post-mortem quantitation of amphetamine in cadaveric fluids in Saudi Arabia. Forensic Science, 2, 222–237. https://doi.org/10.3390/forensicsci2010017
Anna, & Moszczynska. (2016). Neurobiology and clinical manifestations of methamphetamine neurotoxicity. Psychiatric Times, 33(9), 16–18. https://pubmed.ncbi.nlm.nih.gov/30220787/
Attafi, I., Tumayhi, M. M., Banji, D., Albeishy, M. Y., Khardali, I. A., & Korashy, H. M. (2021). Analysis of fatalities involving amphetamine in Jazan, Saudi Arabia. Forensic Science International: Reports, 4, Article 100237. https://doi.org/10.1016/j.fsir.2021.100237
Degenhardt, L., Whiteford, H., & Hall, W. D. (2014). The Global Burden of Disease projects: What have we learned about illicit drug use and dependence and their contribution to the global burden of disease. Drug and Alcohol Review, 33(1), 4–12. https://doi.org/10.1111/dar.12088
Idayani, S., & Putri, N. L. N. D. D. (2020). Hubungan perilaku merokok dengan penggunaan napza jenis amphetamin pada mahasiswa perhotelan perguruan tinggi di Kota Denpasar tahun 2019. Bali Medika Jurnal, 7(1), 138–145. https://doi.org/10.36376/bmj.v7i1.124
Jones, A. W., Holmgren, A., & Ahlner, J. (2011). Quantitative analysis of amphetamine in femoral blood from drug-poisoning deaths compared with venous blood from impaired drivers. Bioanalysis, 3, 2195–2204. https://doi.org/10.4155/bio.11.222
Logan, B. K., Fligner, C. L., & Haddix, T. (1998). Cause and manner of death in fatalities involving methamphetamine. Journal of Forensic Sciences, 43(1), 28–34. https://pubmed.ncbi.nlm.nih.gov/9456521/
Marshall, B. D., & Werb, D. (2010). Health outcomes associated with methamphetamine use among young people: A systematic review. Addiction, 105(6), 991–1002. https://doi.org/10.1111/j.1360-0443.2010.02932.x
Martin, D., & Le, J. K. (2023). Amphetamine. In StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK556103/
Mawadhani, A. A., Amalia, A. W., & Balatif, R. (2024). An urgent call for suicide prevention in Indonesia: The clinicians’ role in preventing suicide. Jurnal Psikiatri Surabaya, 13(2), 123–130. https://doi.org/10.20473/jps.v13i2.56307
McKetin, R., Leung, J., Stockings, E., Huo, Y., Foulds, J., Lappin, J. M., et al. (2019). Mental health outcomes associated with the use of amphetamines: A systematic review and meta-analysis. EClinicalMedicine, 16, 81–97. https://doi.org/10.1016/j.eclinm.2019.09.014
Murad Tumayhi, M., Banji, D., Khardali, I., Banji, O. J. F., Alshahrani, S., Alqahtani, S. S., Muqri, S., Abdullah, A., Sherwani, W., & Attaf, I. (2023). Amphetamine-related fatalities and altered brain chemicals: A preliminary investigation using the comparative toxicogenomic database. Molecules, 28(12), 4787. https://doi.org/10.3390/molecules28124787
Perserikatan Bangsa-Bangsa. (2021). Laporan narkoba dunia 2021. United Nations Digital Library. Diakses pada 2025, dari https://digitallibrary.un.org/record/3931425
Ritchie, H., Arriagada, P., & Roser, M. (2021). Opioids, cocaine, cannabis, and other illicit drugs. Our World in Data. https://ourworldindata.org/illicit-drug-use
Sari, Y. P. (2020). Efek penyalahgunaan neuroenhancement. Jurnal Medika Hutama, 2(1), 261–368. http://jurnalmedikahutama.com
Silva, C. D., Neves, A. F., & Dias, A. L. (2014). A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice. Neurotoxicity Research, 25(3), 295–304. https://doi.org/10.1007/s12640-013-9423-2
Tarique, B., & Sorkin, A. (2023). Amphetamine induces sex-dependent loss of the striatal dopamine transporter in sensitized mice. eNeuro, 11(1), 1–15. https://doi.org/10.1523/ENEURO
Triswara, R., & Carolia, N. (2017). Gangguan fungsi kognitif akibat penyalahgunaan amfetamin. Medical Journal of Lampung University, 7(1), 49–53. http://repository.lppm.unila.ac.id/8437/1/1744-2451-1-PB.pdf
United Nations Office on Drugs and Crime (UNODC). (2016). World drug report 2016. Vienna: United Nations Publication. https://www.unodc.org/wdr2016/
World Health Organization (WHO). (2025). Bunuh diri. Diakses pada 24 April 2025, dari https://www.who.int/news-room/fact-sheets/detail/suicide
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 JURNAL RISET RUMPUN ILMU KESEHATAN

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
_001.jpg)




