Studi Literatur : Penambatan Senyawa Komponen Tanaman Kumis Kucing ( Orthosiphon Stamineus Benth ) Sebagai Diuretik Menggunakan Metode Docking
DOI:
https://doi.org/10.55606/jurrikes.v4i1.4511Keywords:
active compounds, diuretic, kumis kucing, molecular docking, Orthosiphon stamineus, phytopharmaceuticalAbstract
Orthosiphon stamineus Benth., commonly known as kumis kucing, is a widely recognized medicinal herb in traditional medicine, particularly valued for its diuretic properties. This study aims to evaluate the potential of active compounds in O. stamineus as diuretic agents through an in silico approach using molecular docking methods. A total of 98 compounds were screened against three diuretic target receptors: 1Z9Y (furosemide receptor), 3HS4 (acetazolamide receptor), and 3VHU (spironolactone receptor). The docking results revealed that lithospermic acid I, dicaffeoyl tartaric acid, and orthosiponone C exhibited lower binding energies compared to standard ligands, indicating higher affinity and stronger molecular interaction stability. Molecular visualization showed that these compounds formed specific interactions, such as hydrogen bonds and π-π stacking, resembling the binding mechanisms of synthetic diuretics. This study highlights the significant potential of O. stamineus to be developed into a natural diuretic phytopharmaceutical. However, further validation through in vitro and in vivo studies is necessary to confirm their efficacy and safety in complex biological systems.
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Amin, S., & Harahap, F. S. (2025). MENGUNGKAP POTENSI DIURETIK DAN ANTIDIABETIK DARI TANAMAN KUMIS KUCING ( ORTHOSIPHON STAMINEUS BENTH .) MELALUI PENDEKATAN DOCKING MOLEKULER. 1(3), 1350–1355.
Arafat, O. M., Tham, S. Y., Sadikun, A., Zhari, I., Haughton, P. J., & Asmawi, M. Z. (2008). Studies on diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in rats. Journal of Ethnopharmacology, 118(3), 354–360.
Daryanto, D. (2020). Orthosiphon Stamineus Sebagai Anti Inflamasi Dan Diuretik Pada Penyakit Gout Arthritis. Jurnal Penelitian Perawat Profesional, 2(3), 295–300.
Fadillah, A., Rusdiaman, & Hendra, S. (2023). Uji Efektivitas Diuretik Kombinasi Rebusan Rimpang Alang-alang (Imperata cylindrical L.) dan Daun Kumis Kucing (Orthosiphon aristatus Benth.) pada Mencit Jantan (Mus musculus). 5(5), 795–800.
Faramayuda, F., Mariani, T. S., Elfahmi, E., & Sukrasno, S. (2021). Orthosiphon Stamineus Benth. as A Potential Herbal Medicine (mini-review). Seminar Nasional Riset Kedokteran, 2(1).
Fu’adah, N. N., Nurmaulawati, R., & Febriana, L. (2022). UJI EFEKTIVITAS DIURETIK KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus sp.) DAN AKAR PEPAYA (Carica papaya L.) PADA MENCIT JANTAN (Mus musculus). WARTA BHAKTI HUSADA MULIA: Jurnal Kesehatan, 9(1).
Hasbi, F., Amin, S., & Nofianti, T. (2019). PENAMBATAN SENYAWA KOMPONEN TANAMAN KUMIS KUCING ( Orthosiphon stamineus Benth) SEBAGAI DIURETIK MENGGUNAKAN METODE DOCKING.
Kurniawan, A., Siswandono, E. M., & Abdillah, S. (2022). Studi Docking Molekuler dan Toksisitas Senyawa Bioaktif Fukoidan Rumput Laut Coklat yang Berpotensi Sebagai Antihipertensi Secara In Silico In Silico Molecular Docking and Toxicity Studies of Bioactive Fucoidan Compound from Brown Seaweed as Potential of. Pharmacon J Farm Indones, 19, 1–9.
Madyastuti, R., Widodo, S., Purwaningsih, E. H., & Harlina, E. (2020). Aktivitas diuretik dan analisa mineral urin perlakuan ekstrak tanaman kumis kucing (Orthosiphon stamineus Benth) pada tikus jantan. Acta VETERINARIA Indonesiana, 8(2), 16–23.
Madyastuti, R., Wientarsih, I., Widodo, S., Purwaningsih, E. H., & Harlina, E. (2020). Aktivitas Diuretik dan Analisa Mineral Urin Perlakuan Ekstrak Tanaman Kumis Kucing ( Orthosiphon Stamineus Benth ) pada Tikus Jantan The Diuretic Activity and Urin Mineral Analysis of Cat Wishker ’ s Extract. 8(2), 16–23.
Mulia, Y. (2016). Studi Docking Molekuler dan Toksisitas Senyawa Bioaktif Fukoidan Rumput Laut Coklat yang Berpotensi Sebagai Antihipertensi Secara In Silico. 11(2), 1–23.
Muliana, G. H. (2024). Exploring the Potential of Orthosiphon Stamineus: A Literature Review. Jurnal Serambi Engineering, 9(4).
Nadeak, N. A. C., & Roza, D. (2021). Studi Docking Molekuler Senyawa Turunan Kurkuminoid Pada Kunyit (Curcuma longa Linn.) Sebagai Inhibitor Protein Kinase MEK1 Sel Kanker Otak Dengan Autodock Vina.
Rifaldy, D., & Manalu, R. T. (2024). Studi In-Silico Senyawa Flavonoid Herba Kumis Kucing ( Orthosiphon stamineus B .) sebagai Penghambat Enzim Siklooksigenase-2. 21(1).
Roza, D., Selly, R., Munsirwan, R., & Fadhilah, G. (2021). Molecular docking of quinine derivative as inhibitor in Sars-Cov-2. Journal of Physics: Conference Series, 1819(1), 12053.
Sari, I. wulan, Junaidin, & Pratiwi, D. (2020). STUDI MOLECULAR DOCKING SENYAWA FLAVONOID HERBA KUMIS KUCING (Orthosiphon stamineus B.) PADA RESEPTOR -GLUKOSIDASE SEBAGAI ANTIDIABETES TIPE 2 MOLECULAR. VII(2), 54–60.
Sitohang, R., & Sulisty, Y. (2020). UJI AKTIVITAS DIURETIK INFUSA KUMIS KUCING (Orthosiphon stamineus Benth.) PADA TIKUS PUTIH JANTAN (Rattus Norvegicus) GALUR WISTAR. JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS), 2(1), 104–109.
Suriyeni, D., Mukarromah, Z., Ridho, M. R., & Ridho, M. A. (2024). Eksplorasi Molecular Docking Senyawa Flavonoid Orthosiphon Stamineus B. Reseptor Enzim Siklooksigenase (COX) Sebagai Antiinflamasi. Blantika: Multidisciplinary Journal, 2(8).
Trott, O., & Olson, A. J. (2010). AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31(2), 455–461.
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