Eccrine Poroma pada Kulit Kepala: Laporan Kasus dan Tinjauan Histopatologis

Ekawaty Suryani Mastari; Bayu Irvia Satria; Fahmi Irsan Nasution

doi:10.55606/jurrike.v4i2.6228

Authors

Ekawaty Suryani Mastari Institut Kesehatan Helvetia
Bayu Irvia Satria Institut Kesehatan Helvetia
Fahmi Irsan Nasution Institut Kesehatan Helvetia

DOI:

https://doi.org/10.55606/jurrike.v4i2.6228

Keywords:

Poroma, tubular, intraepidermal

Abstract

Poromas are benign neoplasms composed of epithelial cells that show tubular differentiation, which arises from the intraepidermal part of the eccrine of the sweat glands. This lesion can resemble melanoma or non melanoma.^1,2 Case description We reported a case of eccrine poroma in a man, Mr. ES, 50 years old, with complaints of a lump in the head of the temporal region of the region. On macroscopic examination, a blackish-brown scalp tissue size 2x1x0.5 was received, the surface was uneven, the consistency was springy. Microscopic examination of squamous epithelial coating with round, oval, monotone, smooth chromatin, eosinophilic cytoplasm appear. In the sub-epithelium, there is a mass of tumors consisting of proliferative eccrine glands, in groups forming islands, with cuboidal coatings, with round, oval, monotonous nuclei, fine chromatin, eosinophilic cytoplasm. The stroma consists of fibrous connective tissue and blood vessels. The sebaceous glands, hair follicles and infiltration of lymphocyte cells appear. Discussion and conclusions: Based on the results of histopathological examination, it can be concluded as eccrine poroma. In this case electrosurgery is performed, removal with the help of a carbon dioxide laser, or excision surgery can be performed.

Downloads

Download data is not yet available.

References

Akalin, T., Sen, S., Yücetürk, A., & Kandiloğlu, G. (2001). P53 protein expression in eccrine poroma and porocarcinoma. The American Journal of Dermatopathology, 23(5), 402–406. https://doi.org/10.1097/00000372-200110000-00003

Akay, B. N., Erol Mart, H. M., & Okcu Heper, A. (2025). Dermoscopic features of eccrine poromas in diverse skin phototypes: A retrospective study of 26 cases. Dermatology Practical & Conceptual, 15(2), 5071. https://doi.org/10.5826/dpc.1502a5071

Behbahani, S., Malerba, S., Karanfilian, K. M., Warren, C. J., Alhatem, A., & Samie, F. H. (2020). Demographics and outcomes of eccrine porocarcinoma: Results from the National Cancer Database. The British Journal of Dermatology, 183(1), 161–163. https://doi.org/10.1111/bjd.18874

Benchine, A., Loukili, N., Sassi, S., Fatima, E. H., El Youssfi, M., & Bargach, S. (2024). Eccrine poroma in the breast mimicking malignancy: A case report and review of the literature. ASEAN Journal of Psychiatry, 01–04. https://doi.org/10.54615/2231-7805.10.1.133

Bosic, M., Kirchner, M., Brasanac, D., Leichsenring, J., Lier, A., Volckmar, A.-L., Oliveira, C., Buchhalter, I., Stögbauer, F., Zivkovic-Perisic, S., Goeppert, B., Schirmacher, P., Penzel, R., Endris, V., & Stenzinger, A. (2018). Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas. Pathology, 50(3), 327–332. https://doi.org/10.1016/j.pathol.2017.10.011

Chessa, M. A., Patrizi, A., Baraldi, C., Fanti, P. A., Barisani, A., & Vaccari, S. (2019). Dermoscopic-histopathological correlation of eccrine poroma: An observational study. Dermatology Practical & Conceptual, 9(4), 283–291. https://doi.org/10.5826/dpc.0904a07

Choi, I. H., Yu, D. S., & Lee, Y. B. (2020). A case of eccrine poromatosis in a patient with a history of chemotherapy due to stomach cancer. Annals of Dermatology, 32(5), 422–425. https://doi.org/10.5021/ad.2020.32.5.422

Eroschenko, V. P., & Fiore, M. S. H. di. (2008). DiFiore’s atlas of histology with functional correlations (11th ed.). Wolters Kluwer Health/Lippincott Williams & Wilkins.

Ha, D.-L., Lee, G.-W., Shin, K., Kim, H.-S., Ko, H.-C., Kim, B.-S., & Kim, M.-B. (2021). Characteristic clinical and dermoscopic features of nonvolar poroma. Journal of Cutaneous Medicine and Surgery, 25(2), 142–149. https://doi.org/10.1177/1203475420952432

Harms, P. W., Hovelson, D. H., Cani, A. K., Omata, K., Haller, M. J., Wang, M. L., Arps, D., Patel, R. M., Fullen, D. R., Wang, M., Siddiqui, J., Andea, A., & Tomlins, S. A. (2016). Porocarcinomas harbor recurrent HRAS-activating mutations and tumor suppressor inactivating mutations. Human Pathology, 51, 25–31. https://doi.org/10.1016/j.humpath.2015.12.015

Kang, S., Amagai, M., Bruckner, A. L., Enk, A. H., Margolis, D. J., McMichael, A. J., & Orringer, J. S. (2019). Fitzpatrick’s dermatology (9th ed.). McGraw-Hill Education. https://accessmedicine.mhmedical.com/content.aspx?aid=1160945440

Kim, H. J., Kim, A., Moon, K.-C., Seo, S. H., Kim, I.-H., Kim, A., & Baek, Y. S. (2020). Eccrine porocarcinoma: A multicenter retrospective study with review of the literatures reported in Korea. Annals of Dermatology, 32(3), 223–229. https://doi.org/10.5021/ad.2020.32.3.223

Kolarsick, P. A. J., Kolarsick, M. A., & Goodwin, C. (2011). Anatomy and physiology of the skin. Skin Cancer. https://doi.org/10.1097/JDN.0b013e3182274a98

Kumar, V., Abbas, A. K., & Aster, J. C. (Eds.). (2021). Robbins & Cotran pathologic basis of disease (10th ed.). Elsevier.

Kyrmanidou, E., Fotiadou, C., Kemanetzi, C., Trakatelli, M.-G., Trigoni, A., Patsatsi, A., Apalla, Z., & Lazaridou, E. (2023). Eccrine poroma: Pathogenesis, new diagnostic tools and association with porocarcinoma—A review. Diagnostics (Basel, Switzerland), 13(16), 2689. https://doi.org/10.3390/diagnostics13162689

Miller, A. C., Adjei, S., Temiz, L. A., Gill, P., Siller, A., & Tyring, S. K. (2022). Dermal duct tumor: A diagnostic dilemma. Dermatopathology (Basel, Switzerland), 9(1), 36–47. https://doi.org/10.3390/dermatopathology9010007

Moon, J., Lee, J. S., Park, H.-S., Yoon, H.-S., & Cho, S. (2018). Eccrine poroma with rapid growth during pregnancy: A case report and review of the literature. Annals of Dermatology, 30(2), 222–225. https://doi.org/10.5021/ad.2018.30.2.222

O’Dowd, G., Bell, S., & Wright, S. (2024). Wheater’s functional histology: A text and colour atlas (7th ed.). Elsevier.

Puttonen, M., Almusa, H., Böhling, T., Koljonen, V., & Sihto, H. (2025). Whole-exome sequencing identifies distinct genomic aberrations in eccrine porocarcinomas and poromas. Orphanet Journal of Rare Diseases, 20(1). https://doi.org/10.1186/s13023-025-03586-7

Riera-Leal, L., Guevara-Gutiérrez, E., Barrientos-García, J. G., Madrigal-Kasem, R., Briseño-Rodríguez, G., & Tlacuilo-Parra, A. (2015). Eccrine porocarcinoma: Epidemiologic and histopathologic characteristics. International Journal of Dermatology, 54(5), 580–586. https://doi.org/10.1111/ijd.12714

Sano, D., Yang, J., de Lima Junior, C., & Pegas, J. (2014). Pigmented eccrine poroma simulating malignant melanoma. Surgical & Cosmetic Dermatology.