Jalur Saraf Vergence : Systematic Literature Review
DOI:
https://doi.org/10.55606/jurrike.v4i1.4548Keywords:
Neural Pathways, Systematic Literature Review, VergenceAbstract
Vergence movement is an important mechanism in eye coordination to maintain visual focus. The neural pathways controlling vergence involve complex interactions between various brain structures, such as the mesencephalic nucleus of the oculomotor nerve (CN III), the abducens nucleus (CN VI), the reticular pontine formation (PRF), and the visual and motor cortices. Disorders in this system can lead to convergence insufficiency, esotropia, exotropia, as well as diplopia which impacts the quality of binocular vision. This study aims to conduct a systematic review of the neural pathways that play a role in the vergence system. This research design is a study that uses the Systematic Literature Review (SLR) method. 5 articles were obtained using a method of secondary analysis of literature review through scientific database portals such as SINTA, Scopus and Google Scholar published in 2015-2025 both national and international articles. The results of the analysis show that vergence disorders are common in children and the elderly, with various causes ranging from benign factors to more serious neurological conditions. Studies show that activities in the parietal eye field (PEF), frontal eye field (FEF), superior colliculus (SC), and PRF have important roles in vergence coordination. In addition, vergence deficits were also found in Parkinson's patients, who showed prolonged latency and reduced vergence gain. In the context of technology, research on virtual reality (VR) shows that vergence errors often occur when users interact with virtual environments, leading to visual fatigue and incorrect depth perception. This study also highlights that neurotransmitters such as GABA, glutamate, and dopamine have a role in the modulation of neural signals that control vergence. A deeper understanding of the neural pathways of vergence is crucial in ophthalmology and neurology, especially in the diagnosis and therapy of binocular vision disorders. In addition, research on vergence also contributes to the development of visual technologies, such as VR and eye tracking systems, that are more adaptive to human physiological characteristics.
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References
correlates of neural control of ocular movements. European Radiology, 26, 2193–2205. https://doi.org/10.1007/s00330-015-4055-3
Brune, A. J., & Eggenberger, E. R. (2018). Disorders of vergence eye movements. Current Treatment Options in Neurology, 20, 1–8. https://doi.org/10.1007/s11940-018-0524-z
Chen, Y.-F., Lee, Y.-Y., Chen, T., Semmlow, J. L., Alvarez, T. L., & others. (2010). Behaviors, models, and clinical applications of vergence eye movements. Journal of Medical and Biological Engineering, 30(1), 1–15.
Ciuffreda, K. J., Tannen, B., Singman, E., & Han, M. H. (2020). Evaluation and treatment of visual dysfunction. In Brain Injury Medicine (pp. xx–xx). Springer/Demos.
Cohen, A. H. (2013). Vision rehabilitation for visual-vestibular dysfunction: The role of the neuro-optometrist. NeuroRehabilitation, 32(3), 483–492. https://doi.org/10.3233/NRE-130870
Coubard, O. A. (2013). Saccade and vergence eye movements: A review of motor and premotor commands. European Journal of Neuroscience, 38(10), 3384–3397. https://doi.org/10.1111/ejn.12348
Dinkin, M. (2014). Diagnostic approach to diplopia. Continuum: Lifelong Learning in Neurology, 20(4), 942–965. https://doi.org/10.1212/01.CON.0000453315.21761.37
Feil, M., Moser, B., & Abegg, M. (2017). The interaction of pupil response with the vergence system. Graefe’s Archive for Clinical and Experimental Ophthalmology, 255, 2247–2253. https://doi.org/10.1007/s00417-017-3755-3
Fernanda, N., Amalia, H., & others. (2018). Hubungan akomodasi insufisiensi dan astenopia pada remaja di Jakarta Barat. Jurnal Biomedika dan Kesehatan, 1(1), 10–17.
Gupta, P., Murray, J. M., Beylergil, S. B., Jacobs, J., Kilbane, C. W., Shaikh, A. G., & Ghasia, F. F. (2023). Objective assessment of eye alignment and disparity-driven vergence in Parkinson’s disease. Frontiers in Aging Neuroscience, 15, 1217765. https://doi.org/10.3389/fnagi.2023.1217765
Hansen, E. (1976). Neurologi. Erlangga.
Iskander, J., Hossny, M., & Nahavandi, S. (2019). Using biomechanics to investigate the effect of VR on eye vergence system. Applied Ergonomics, 81, 102883. https://doi.org/10.1016/j.apergo.2019.102883
Kiyokawa, K. (2015). Head-mounted display technologies for augmented reality. In Fundamentals of Wearable Computing and Augmented Reality (pp. 59–84). https://doi.org/10.1201/b18703
Mays, L. E. (1984). Neural control of vergence eye movements: Convergence and divergence neurons in midbrain. Journal of Neurophysiology, 51(5), 1091–1108. https://doi.org/10.1152/jn.1984.51.5.1091
McAnally, K., Grove, P., & Wallis, G. (2024). Vergence eye movements in virtual reality. Displays, 83, 102683. https://doi.org/10.1016/j.displa.2023.102683
Meidian, A. C., & Maratis, J. (n.d.). Modul Mata Kuliah Neurosains (FNS 216).
Muchlis, I., Maulana, R., & Fitriyah, H. (2018). Implementasi pengenalan pergerakan bola mata menggunakan elektroda dengan exponential filter. Jurnal Pengembangan Teknologi Informasi dan Ilmu Komputer, 2(9), 3093–3102.
Padungkiatsagul, T., & Moss, H. E. (2020). Cranial Neuropathies II, III, IV, and VI. In Hankey’s Clinical Neurology (pp. 693–716). CRC Press.
Prayitnaningsih, S., Rohman, M. S., Sujuti, H., Abdullah, A. A. H., & Vierlia, W. V. (2021). Pengaruh hipertensi terhadap glaukoma. Universitas Brawijaya Press.
Purwadhi, P., Widjaja, Y. R., Lukas, D. C., & Hapa, M. (2025). Implementasi Balanced Scorecard sebagai alat pengukuran kinerja di rumah sakit: Systematic Literature Review. EKOMA: Jurnal Ekonomi, Manajemen, Akuntansi, 4(2), 3548–3556.
Searle, A., & Rowe, F. J. (2016). Vergence neural pathways: A systematic narrative literature review. Neuro-Ophthalmology, 40(5), 209–218. https://doi.org/10.3109/01658107.2016.1171804
Straumann, D. (2007). Disconjugate eye movements. Developments in Ophthalmology, 40, 90–106. https://doi.org/10.1159/000100428
Syauqie, M., & Putri, S. H. M. (2014). Development of binocular vision. Jurnal Kesehatan Andalas, 3(1), xx–xx.
Taub, E., Mark, V. W., Uswatte, G., Perez, C., Chokron, S., Urbanski, M., … others. (2015). PART III--Visual training programs in organic deficits and their neural bases. In Neurovision: Neural Bases of Binocular Vision and Coordination and Their Implications in Visual Training Programs (Vol. 5).
Wang, K., Han, G., & Hao, R. (2024). Advances in the study of the influence of photoreceptors on the development of myopia. Experimental Eye Research, 245, 109976. https://doi.org/10.1016/j.exer.2024.109976
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