Peran Vitamin D dalam Pencegahan Preeklampsia pada Ibu Hamil: Article Review
DOI:
https://doi.org/10.55606/jurrike.v5i2.10216Keywords:
25-Hydroxyvitamin D, Preeclampsia, Pregnancy, Supplementation, Vitamin DAbstract
Preeclampsia is a hypertensive disorder of pregnancy that contributes substantially to maternal and perinatal morbidity and mortality. Vitamin D may influence placentation, immune regulation, endothelial function, angiogenesis, and the renin–angiotensin system; therefore, low vitamin D status has been associated with preeclampsia risk. This structured literature review covered publications from the last 10 years (2016–11 August 2026), prioritizing randomized controlled trials, systematic reviews/meta-analyses, umbrella reviews, and relevant clinical or public-health guidance. Several recent meta-analyses reported lower preeclampsia incidence with vitamin D supplementation, with effect estimates around RR 0.55–0.62 or OR 0.50–0.58. Nevertheless, the evidence is not fully consistent. The 2024 Cochrane update judged the evidence for vitamin D alone on preeclampsia to be very uncertain after studies with trustworthiness concerns were excluded. Heterogeneity in baseline 25-hydroxyvitamin D status, dose, timing, comparators, maternal risk profiles, and study quality remains substantial. Vitamin D has biological plausibility and a possible adjunctive preventive role, particularly among women with deficiency, but current evidence is insufficient to support universal vitamin D supplementation specifically for preeclampsia prevention. Well-powered multicenter trials with standardized baseline assessment, dosing regimens, safety monitoring, and adjudicated preeclampsia phenotypes are required.
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AlSubai, A., Baqai, M. H., Agha, H., Shankarlal, N., Javaid, S. S., Jesrani, E. K., Golani, S., Akram, A., Qureshi, F., Ahmed, S., & Saran, S. (2023). Vitamin D and preeclampsia: A systematic review and meta-analysis. SAGE Open Medicine, 11, Article 20503121231212093. https://doi.org/10.1177/20503121231212093
Chien, M.-C., Huang, C.-Y., Wang, J.-H., Shih, C.-L., & Wu, P. (2024). Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic reviews and meta-analyses. Nutrition & Diabetes, 14, Article 35. https://doi.org/10.1038/s41387-024-00296-0
Dimitriadis, E., Rolnik, D. L., Zhou, W., Estrada-Gutierrez, G., Koga, K., Francisco, R. P. V., Whitehead, C., Hyett, J., da Silva Costa, F., Nicolaides, K., & Menkhorst, E. (2023). Pre-eclampsia. Nature Reviews Disease Primers, 9(1), Article 8. https://doi.org/10.1038/s41572-023-00417-6
Fogacci, S., Fogacci, F., Banach, M., Michos, E. D., Hernandez, A. V., Lip, G. Y. H., Blaha, M. J., Toth, P. P., Borghi, C., & Cicero, A. F. G. (2020). Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials. Clinical Nutrition, 39(6), 1742–1752. https://doi.org/10.1016/j.clnu.2019.08.015
Gallo, S., McDermid, J. M., Al-Nimr, R. I., Hakeem, R., Moreschi, J. M., Pari-Keener, M., Stahnke, B., Papoutsakis, C., Handu, D., & Cheng, F. W. (2020). Vitamin D supplementation during pregnancy: An evidence analysis center systematic review and meta-analysis. Journal of the Academy of Nutrition and Dietetics, 120(5), 898–924.e4. https://doi.org/10.1016/j.jand.2019.07.002
Irwinda, R., Hiksas, R., Lokeswara, A. W., & Wibowo, N. (2022). Vitamin D supplementation higher than 2000 IU/day compared to lower dose on maternal-fetal outcome: Systematic review and meta-analysis. Women’s Health, 18, Article 17455057221111066. https://doi.org/10.1177/17455057221111066
Kabuyanga, R. K., Tugirimana, P. L., Sifa, B., Balezi, M., Dikete, M. E., Mitangala, P. N., Elongi, J. P. M., Kinenkinda, X. K., & Kakoma, J.-B. S. Z. (2024). Effect of early vitamin D supplementation on the incidence of preeclampsia in primigravid women: A randomised clinical trial in Eastern Democratic Republic of the Congo. BMC Pregnancy and Childbirth, 24, Article 107. https://doi.org/10.1186/s12884-024-06277-6
Kartasurya, M. I., Stacey, T., Lisnawati, N., & Sulistianingsih, A. R. (2025). A systematic review and meta-analysis on the effect of vitamin D in preeclampsia and gestational diabetes mellitus in pregnancy. AIMS Public Health, 12(4), 1223–1239. https://doi.org/10.3934/publichealth.2025062
Kokkinari, A., Antoniou, E., Orovou, E., Andronikidi, P. E., Tzitiridou-Chatzopoulou, M., Sarantaki, A., Gourounti, K., & Iatrakis, G. (2025). The role of vitamin D supplementation in preventing pre-eclampsia: A review of randomized controlled trials with meta-analysis. Healthcare, 13(11), Article 1221. https://doi.org/10.3390/healthcare13111221
Lin, L., Zhu, Q., Xiao, Y., & Zhang, X. (2026). Vitamin D supplementation during pregnancy and maternal and neonatal outcomes: Results from a quantitative umbrella meta-analysis. BMC Pregnancy and Childbirth, 26, Article 518. https://doi.org/10.1186/s12884-026-08994-6
Mirzakhani, H., Litonjua, A. A., McElrath, T. F., O’Connor, G., Lee-Parritz, A., Iverson, R., Macones, G., Strunk, R. C., Bacharier, L. B., Zeiger, R., Hollis, B. W., Handy, D. E., Sharma, A., Laranjo, N., Carey, V., Qiu, W., Santolini, M., Liu, S., Chhabra, D., ... Weiss, S. T. (2016). Early pregnancy vitamin D status and risk of preeclampsia. Journal of Clinical Investigation, 126(12), 4702–4715. https://doi.org/10.1172/JCI89031
Moghib, K., Ghanm, T. I., Abunamoos, A., Rajabi, M., Moawad, S. M., Mohsen, A., Kasem, S., Elsayed, K., Sayed, M., Dawoud, A. I., Salomon, I., Elmaghreby, A., Ismail, M., & Amer, A. (2024). Efficacy of vitamin D supplementation on the incidence of preeclampsia: A systematic review and meta-analysis. BMC Pregnancy and Childbirth, 24, Article 852. https://doi.org/10.1186/s12884-024-07081-y
Octavius, G. S., Adman Daleni, V., Angeline, G., & Virliani, C. (2023). A systematic review and meta-analysis of prevalence of vitamin D deficiency among Indonesian pregnant women: A public health emergency. AJOG Global Reports, 3(2), Article 100189. https://doi.org/10.1016/j.xagr.2023.100189
Palacios, C., De-Regil, L. M., Lombardo, L. K., & Peña-Rosas, J. P. (2016). Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes. The Journal of Steroid Biochemistry and Molecular Biology, 164, 148–155. https://doi.org/10.1016/j.jsbmb.2016.02.008
Palacios, C., Kostiuk, L. L., Cuthbert, A., & Weeks, J. (2024). Vitamin D supplementation for women during pregnancy. Cochrane Database of Systematic Reviews, 2024(7), Article CD008873. https://doi.org/10.1002/14651858.CD008873.pub5
Purswani, J. M., Gala, P., Dwarkanath, P., Larkin, H. M., Kurpad, A., & Mehta, S. (2017). The role of vitamin D in pre-eclampsia: A systematic review. BMC Pregnancy and Childbirth, 17, Article 231. https://doi.org/10.1186/s12884-017-1408-3
Roth, D. E., Leung, M., Mesfin, E., Qamar, H., Watterworth, J., & Papp, E. (2017). Vitamin D supplementation during pregnancy: State of the evidence from a systematic review of randomised trials. BMJ, 359, Article j5237. https://doi.org/10.1136/bmj.j5237
Sunarno, R. D., Kartasurya, M. I., Suwondo, A., & Rahfiludin, M. Z. (2023). Vitamin D supplementation and sun exposure maintain blood pressures of pregnant women and increase birth weight in a randomized controlled trial. Iranian Journal of Public Health, 52(10), 2148–2156. https://doi.org/10.18502/ijph.v52i10.13853
Ushida, T., Tano, S., Matsuo, S., Fuma, K., Imai, K., Kajiyama, H., & Kotani, T. (2025). Dietary supplements and prevention of preeclampsia. Hypertension Research, 48(4), 1444–1457. https://doi.org/10.1038/s41440-025-02144-9
World Health Organization. (2023, August 9). Vitamin D supplementation during pregnancy. https://www.who.int/tools/elena/interventions/vitamind-supp-pregnancy
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