Uji Efektivitas Anxiolytic Ekstrak Teh Hijau (Camellia Sinensis) terhadap Tikus Model Kecemasan Dengan Metode Elevated Plus Maze

M. Fiqri Maulana Harahap; Ilham Hariaji

doi:10.55606/jurrike.v5i2.10169

Authors

M. Fiqri Maulana Harahap Universitas Muhammadiyah Sumatera Utara
Ilham Hariaji Universitas Muhammadiyah Sumatera Utara

DOI:

https://doi.org/10.55606/jurrike.v5i2.10169

Keywords:

Anxiety, Camellia Sinensis, Elevated Plus Maze, Forced Swim Test, L-Theanine

Abstract

Introduction: Green tea (Camellia sinensis) is known for its anxiolytic benefits derived from L-theanine, EGCG, and caffeine, which influence neurotransmitters like GABA and dopamine and enhance alpha brain wave activity. Methods: This experimental study employed a post-test only with control group design. The subjects were 27 male Wistar rats induced with anxiety using the Forced Swim Test. Treatment was administered with green tea extract at a dose of 3.6 mg/kgBW. Anxiety levels were measured using the Elevated Plus Maze (EPM) method, focusing on the duration spent in open arms. Statistical analysis was conducted using One-Way ANOVA, followed by post-hoc Tukey tests to identify significant differences between groups. Results: The treatment group showed an average time in open arms of 114.22 seconds, approaching the positive control (fluoxetine ) at 117.67 seconds, and higher than the negative control (Placebo) at 90.33 seconds. Statistical analysis indicated significant differences among treatment groups (p < 0.001). Conclusion: Green tea extract demonstrated significant anxiolytic effects in reducing anxiety in a rat model.

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